Gyne Cancers Flashcards
Most common gynecological cancer in developed countries
endometrial cancer
Type of endometrial CA that includes Grade 1 and 2 are estrogen sensitive and
carry a good prognosis
Type 1 (80%)
Type of endometrial CA that are grade 3 endometrioid tumors
type 2 (20%)
Type of endometrial CA that has a better prognosis than adenosquamous, papillary, serour, or clear cell types
endometriod (estrogen sensitive)
How much blood in a menopausal or postmenopausal women require work-up
one drop
Presentation includes perimenopausal woman w/irregular vaginal bleeding or postmenopausal woman w/new onset bleeding
endometrial CA
Work-up for endometiral CA
pelvic exam, urine/serum HCG, Ultrasound
Prevention of endometrial CA
progestin w/estrogen, diet/excercise/weight control
Cancer that affects females of all ages
ovarian cancer
Most common tissue type of ovarian cancers
epithelial (85-90%)
Symptoms include: abdominal distention, abdominal/pelvic pressure, anorexia, nausea, early satiety, dyspnea
ovarian cancer
When should you suspect ovarian cancer in women between 40-80yrs?
any woman with persistant GI symptoms
Genes that increase risk of ovarian cancer
BRCA1 and BRCA2
Markers that can be used in the detection of ovarian cancer
CA-125 and HE4
Mean age for cervical cancer
47 yrs
Most common type of cervical cancer
squamous cell (85-90%)
Etiology of cervical cancer
oncogenic HPV
Screening for cervical cancer
pap smear
Percentage of sexually active women who will aquire HPV
80%. Most will be cleared in 12-18 months
Oncogenic types of HPV
16, 18, 45
What are non-oncogenic types of cervical cancer associated with?
formation of condylomata
Types of HPV covered by vaccine
6, 11, 16, 18
Non-oncogenic types of HPV
6 and 11
Pregnancy category for HPV vaccine
category B. okay to give when lactating
