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Oncology > Breast Cancer > Flashcards

Breast Cancer Flashcards

1
Q

Among these, proliferative lesions (especially those with histologic atypia) are associated with an increased risk of breast cancer

A

benign breast disease

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2
Q

T/F the more connective tissue a breast has, the more likely it will develop breast cancer

A

true

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3
Q

consistently associated with a higher risk of breast cancer among postmenopausal women

A

A higher BMIand/orperimenopausal weight gain

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4
Q

Type of work that is now recognized by WHO as a probable carcinogen

A

night shift work

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5
Q

Contributors to cumulative lifetime exposure to estrogen

A

early menarche, late menopause, no breastfeeding, BC, postmenopausal hormone therapy

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6
Q

inherited as autosomal dominant, highly penetrant, germline mutations that are associated with an inherited susceptibility to breast and ovarian cancer.

A

BRCA1 and BRCA2

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7
Q

Women taller than what height have a higher risk of breast cancer?

A

> 175 cm

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8
Q

Male risk factors for breast cancer

A

klinefelter’s, testicular/liver pathology, family h/o and BRCA2

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9
Q

Recommended age group for annual mammograms

A

50-74

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10
Q

Screening recommendations for women at high risk of breast cancer

A

Annual mammogram and MRI starting at age 25. Clinical breast exam every 3-6 months

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11
Q

Recommendationg for annual breast exams

A

every 2-3 yrs from 20-39, then annually

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12
Q

How long should you examine each breast?

A

3-5 minutes

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13
Q

Percentage of breast cancers found on mammogram

A

80-90%

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14
Q

Type of breast CA where neoplastic lesions confined to the breast ducts and lobules

A

Noninvasive (DCIS)

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15
Q

affects 1 breast. will go on to develop a recurrence or an invasive ductal carcinoma within 10 years if they’ve only been treated with a limited biopsy

A

Ductal carcinoma in situ

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16
Q

These lesions are most often identified on mammograms as clustered microcalcifications with or without a palpable mass

A

Ductal carcinoma in situ

17
Q

Tx of Ductal carcinoma in situ

A

breast conserving tx

18
Q

Invasive cancers can develop in either breast. will go on to develop invasive lobular carcinoma or invasive ductal carcinoma within 20 years if a limited biopsy was performed

A

Lobular carcinoma in situ (LCIS)‏

19
Q

Tx of Lobular carcinoma in situ (LCIS)‏

A

excisional biopsy or BCT

20
Q

never a palpable lesion and no characteristic mammographic appearance

A

Lobular carcinoma in situ (LCIS)‏

21
Q

Most common type of invasive breast cancer

A

Infiltrating ductal carcinomas 70-80%

22
Q

T/F All patients should undergo surgery following neoadjuvant systemic therapy, even if they have a complete clinicaland/orradiological response

A

true

23
Q

Name the two most rare invasive breast cancers

A

Paget’s Dz and infammatory breast CA

24
Q

Disorder of the nipple and areola. Eczematoid appearance w/ crusting, scaling and erosion. Breast cancer cells within the nipple and areolar epidermis

A

Paget’s Dz

25
Q

Always associated w/ underlying mammary carcinoma either in situ or invasive

A

Paget’s Dz

26
Q

Rapidly progressive tumor w/ high chance for early metastases. Presentation includes: painful, tender, firm enlarged breast. Skin has peau d’orange appearance

A

inflammatory breast CA

27
Q

Removal of breast and associated lymph nodes

A

modified radical mastectomy

28
Q

selective estrogen receptor modulators (SERMS) that is beneficial in tumors that are ER/PR positive

A

tamoxifen

29
Q

Greatest risk for recurrence of breast cancer

A

within the first 5 yrs

30
Q

How often should a woman with h/o of breast cancer have a H&P and mammograms?

A

every 3-6 months first 3 years. Then every 6-12 months for 2 years. then annually

Oncology (13 decks)

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