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Heme-Onc > Lymphoma Flashcards > Flashcards

Lymphoma Flashcards

1
Q

painful LAD

A

acute infection (reactive LAD)

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2
Q

painless LAD

A

chronic inflammation; metastatic carcinoma; lymphoma

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3
Q

area of lymph node where T-cells live

A

paracortex

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4
Q

area of lymph node where B-cells live

A

cortex

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5
Q

area of lymph node where sinus histiocytes live

A

medulla

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6
Q

zones of cortex of lymph node (from inside –> out)

A

follicle; mantle; margin (sometimes)

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7
Q

3 lymphomas that arrise from small neoplastic B cells

A

follicular; mantle cell; marginal

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8
Q

key marker for B-cells

A

CD20

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9
Q

cancer presenting in adulthood with painless lymphadenopathy, neoplastic small CD20+ cells that make follicle-like nodules

A

follicular lymphoma

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10
Q

t(14;18)

A

follicular lymphoma

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11
Q

chromasomal abnormality in follicular lymphoma

A

t(14;18)

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12
Q

what chromosome carries the gene for Bcl2?

A

18

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13
Q

what is the molecular consequence of t(14;18)?

A

overexpression of Bcl2

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14
Q

what cancer is associated with Bcl-2?

A

follicular lymphoma

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15
Q

what chromosome carries the gene for IgH?

A

14

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16
Q

main complication of follicular lymphoma

A

progression to diffuse large B-cell lymphoma (presents as enlarging lymph node)

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17
Q

how can folllicular lymphoma be distinguished from follicular hypertrophy?

A

follicles throughout entire lymph node (not just in cortex); lack of tingible body macrophages in germinal center; expression of Bcl2 in follicles; monoclonality

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18
Q

what do tingible body macrophages in the germinal center of a lymph node indicate?

A

apoptosis

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19
Q

neoplastic proliferation of small B cells (CD20+) that expand the area surrounding follicle

A

mantle cell lymphoma

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20
Q

chromosomal abnormality in mantle cell lymphoma

A

t(11;14)

21
Q

what is the molecular consequence of t(11;14)?

A

overexpression of cyclinD1 (promotes G1/S transition by phosphorylating regulators)

22
Q

neoplastic small CD20+ cells that expand the area surrounding the mantle

A

marginal zone lymphoma

23
Q

type of lymphoma associated with chronic inflammatory states

A

marginal zone lymphoma

24
Q

what type of cells form the marginal zone of a lymph node?

A

post-germinal center B-cells

25
Q

type of lymphoma associated with H Pylori infection

A

gastric MALToma (marginal zone lymphoma in mucosal sites)

26
Q

neoplastic proliferation of intermediate-sized B-cells

A

Burkitt lymphoma

27
Q

what virus is associated with burkitt lymphoma?

A

EBV

28
Q

extranodal mass in African child involving the jaw

A

Burkitt lymphoma

29
Q

where in the body does sporadic burkitt lymphoma develop?

A

abdomen

30
Q

chromosomal abnormality in burkitt lymphoma

A

t(8;14)

31
Q

what is the molecular consequence of t(8;14)?

A

overexpression of c-MYC (promotes cell growth)

32
Q

on what chromosome is MYC located?

A

8

33
Q

cancer with starry sky appearance on histology

A

burkitt lymphoma

34
Q

neoplastic proliferation of large B-cells (CD20+) that grow diffusely in sheets

A

diffuse large b-cell lymphoma (DLBCL)

35
Q

most common form of NHL

A

DLBCL

36
Q

type of lymphoma that can arise from follicular lymphoma

A

DLBCL

37
Q

reed-sternberg cell histology

A

large B cell with multilobed nuclei and prominent nucleoli

38
Q

neoplastic proliferation of reed-sternberg cells

A

hodgkin lymphoma

39
Q

CD15+ and CD30+

A

reed-sternberg cells

40
Q

“owl eyed” nucleus

A

reed-sternberg cells

41
Q

what forms the bulk of the tumor in hodgkin lymphoma?

A

reactive inflammatory cells attracted by cytokines from reed-sternberg cell (lymphocytes, plasma cells, macrophages, eosinophils)

42
Q

what type of lymphoma can present with “B” symptoms (fevers, chills, night sweats)

A

hodgkin lymphoma

43
Q

most common form of hodgkin lymphoma

A

nodular sclerosis

44
Q

classic presentation is young female with enlarging cervical neck or mediastinal lymphnode

A

nodular sclerosis

45
Q

lymph nodes divided by broad bands of fibrosis

A

hodgkin lymphoma - nodular sclreosis

46
Q

special kind of reed-sternberg cell seen in nodular sclerosis hodgkin lymphoma subtype

A

lacunar cells

47
Q

which type of hodgkin lymphoma has the best prognosis

A

lymphocyte-rich

48
Q

which type of hodgkin lymphoma is associated with eosinophils (IL-5)

A

mixed cellularity

49
Q

which type of hodgkin lymphoma has the worst prognosis?

A

lymphocyte-depleted

Heme-Onc (11 decks)

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