Lymphoma

Question 1

painful LAD

Answer 1

acute infection (reactive LAD)

Question 2

painless LAD

Answer 2

chronic inflammation; metastatic carcinoma; lymphoma

Question 3

area of lymph node where T-cells live

Answer 3

paracortex

Question 4

area of lymph node where B-cells live

Answer 4

cortex

Question 5

area of lymph node where sinus histiocytes live

Answer 5

medulla

Question 6

zones of cortex of lymph node (from inside –> out)

Answer 6

follicle; mantle; margin (sometimes)

Question 7

3 lymphomas that arrise from small neoplastic B cells

Answer 7

follicular; mantle cell; marginal

Question 8

key marker for B-cells

Answer 8

CD20

Question 9

cancer presenting in adulthood with painless lymphadenopathy, neoplastic small CD20+ cells that make follicle-like nodules

Answer 9

follicular lymphoma

Question 10

t(14;18)

Answer 10

follicular lymphoma

Question 11

chromasomal abnormality in follicular lymphoma

Answer 11

t(14;18)

Question 12

what chromosome carries the gene for Bcl2?

Answer 12

18

Question 13

what is the molecular consequence of t(14;18)?

Answer 13

overexpression of Bcl2

Question 14

what cancer is associated with Bcl-2?

Answer 14

follicular lymphoma

Question 15

what chromosome carries the gene for IgH?

Answer 15

14

Question 16

main complication of follicular lymphoma

Answer 16

progression to diffuse large B-cell lymphoma (presents as enlarging lymph node)

Question 17

how can folllicular lymphoma be distinguished from follicular hypertrophy?

Answer 17

follicles throughout entire lymph node (not just in cortex); lack of tingible body macrophages in germinal center; expression of Bcl2 in follicles; monoclonality

Question 18

what do tingible body macrophages in the germinal center of a lymph node indicate?

Answer 18

apoptosis

Question 19

neoplastic proliferation of small B cells (CD20+) that expand the area surrounding follicle

Answer 19

mantle cell lymphoma

Question 20

chromosomal abnormality in mantle cell lymphoma

Answer 20

t(11;14)

Question 21

what is the molecular consequence of t(11;14)?

Answer 21

overexpression of cyclinD1 (promotes G1/S transition by phosphorylating regulators)

Question 22

neoplastic small CD20+ cells that expand the area surrounding the mantle

Answer 22

marginal zone lymphoma

Question 23

type of lymphoma associated with chronic inflammatory states

Answer 23

marginal zone lymphoma

Question 24

what type of cells form the marginal zone of a lymph node?

Answer 24

post-germinal center B-cells

Question 25

type of lymphoma associated with H Pylori infection

Answer 25

gastric MALToma (marginal zone lymphoma in mucosal sites)

Question 26

neoplastic proliferation of intermediate-sized B-cells

Answer 26

Burkitt lymphoma

Question 27

what virus is associated with burkitt lymphoma?

Answer 27

EBV

Question 28

extranodal mass in African child involving the jaw

Answer 28

Burkitt lymphoma

Question 29

where in the body does sporadic burkitt lymphoma develop?

Answer 29

abdomen

Question 30

chromosomal abnormality in burkitt lymphoma

Answer 30

t(8;14)

Question 31

what is the molecular consequence of t(8;14)?

Answer 31

overexpression of c-MYC (promotes cell growth)

Question 32

on what chromosome is MYC located?

Answer 32

8

Question 33

cancer with starry sky appearance on histology

Answer 33

burkitt lymphoma

Question 34

neoplastic proliferation of large B-cells (CD20+) that grow diffusely in sheets

Answer 34

diffuse large b-cell lymphoma (DLBCL)

Question 35

most common form of NHL

Answer 35

DLBCL

Question 36

type of lymphoma that can arise from follicular lymphoma

Answer 36

DLBCL

Question 37

reed-sternberg cell histology

Answer 37

large B cell with multilobed nuclei and prominent nucleoli

Question 38

neoplastic proliferation of reed-sternberg cells

Answer 38

hodgkin lymphoma

Question 39

CD15+ and CD30+

Answer 39

reed-sternberg cells

Question 40

"owl eyed" nucleus

Answer 40

reed-sternberg cells

Question 41

what forms the bulk of the tumor in hodgkin lymphoma?

Answer 41

reactive inflammatory cells attracted by cytokines from reed-sternberg cell (lymphocytes, plasma cells, macrophages, eosinophils)

Question 42

what type of lymphoma can present with "B" symptoms (fevers, chills, night sweats)

Answer 42

hodgkin lymphoma

Question 43

most common form of hodgkin lymphoma

Answer 43

nodular sclerosis

Question 44

classic presentation is young female with enlarging cervical neck or mediastinal lymphnode

Answer 44

nodular sclerosis

Question 45

lymph nodes divided by broad bands of fibrosis

Answer 45

hodgkin lymphoma - nodular sclreosis

Question 46

special kind of reed-sternberg cell seen in nodular sclerosis hodgkin lymphoma subtype

Answer 46

lacunar cells

Question 47

which type of hodgkin lymphoma has the best prognosis

Answer 47

lymphocyte-rich

Question 48

which type of hodgkin lymphoma is associated with eosinophils (IL-5)

Answer 48

mixed cellularity

Question 49

which type of hodgkin lymphoma has the worst prognosis?

Answer 49

lymphocyte-depleted