Chronic Leukemia

Question 1

neoplastic proliferation of naive B-cells

Answer 1

chronic lymphocytic leukemia

Question 2

characteristic surface markers on B-cells of CLL

Answer 2

co-expression of CD-5 and CD-20 (note: CD-5 normally found on T cells)

Question 3

blood smear shows increased number of lymphocytes and smudge smears

Answer 3

CLL

Question 4

name of CLL involving lymph nodes

Answer 4

small lymphocytic lymphoma

Question 5

findings: hypogammaglobulinemia, autoimmune hemolytic anemia

Answer 5

CLL

Question 6

cause of enlarging spleen/lymph node in CLL

Answer 6

transformation to diffuse large B-cell lymphoma

Question 7

neoplastic proliferation of mature B-cells with hairy cytoplasmic processes

Answer 7

hairy cell leukemia

Question 8

cells are positive for TRAP

Answer 8

hairy cell leukemia

Question 9

clinical features: splenomegaly (red pulp), dry tap with bone marrow, absent lymphoadenopathy

Answer 9

hairy cell leukemia

Question 10

drug used to treat hairy cell leukemia

Answer 10

2-CDA

Question 11

mechanism of 2-CDA

Answer 11

adenosine deaminase inhibitor - adenosine accumulates to toxic levels in neoplastic B cells

Question 12

neoplastic proliferation of mature CD4+ T cells

Answer 12

ATLL

mycosis fungoides

Question 13

this virus is associated with ATLL

Answer 13

HTLV-1 (Japan and Caribbean)

Question 14

HTLV-1 is associated with what type of leukemia

Answer 14

adult T-cell Leukemia/lymphoma (ATLL)

Question 15

clinical features: rash, lytic bone lesions with hypercalcemia

Answer 15

ATLL

Question 16

leukemia associated with Pautrier microabcesses

Answer 16

mycosis fungoides

Question 17

aggregates of neoplastic T-cells in epidermis

Answer 17

pautrier microabcesses

Question 18

cells with cerebreform nuclei in blood smear

Answer 18

sezary syndrome