lymphoma Flashcards
RF Hodgkins lymphoma
HIV, EBV
age of Hodgkins lymphoma
30, and 70
symptoms Hodgkins lymphoma
painless, asymmetrical lymph nodes (neck) - pain with ALCOHOL // B symptoms - weight loss, itch, night sweats, fever
FBC Hodgkins lymphoma
normocytic anaemia // raised eosinophils // raised LDH // (raised ESR = bad)
what is seen on lymph biopsy in Hodgkins lymphoma
reid steenberg cells
types of Hodgkins lymphoma most –> least common (4)
nodular sclerosing // mixed // lymphocyte predominant // lymphocyte depletes
what type of Hodgkins lymphoma has best prognosis
lymphocyte predominant (nodular + mixed also OK)
what type of Hodgkins lymphoma has worst prognosis
lymphocyte depletes
what symptoms in Hodgkins lymphoma indicate bad prognosis
B symptoms: fever 38+ // night sweats // weight loss >10% in 6 months
what staging system is used for Hodgkins lymphoma and what is stage I–>IV
Ann-Arbor // I = single node // II = 2 or more lymph nodes same side of diaphragm // III = lymph nodes both side of diaphragm // IV = spread beyond lymph
what does stage A or B in Hodgkins lymphoma mean
A = non systemic (maybe itch) // B = B symptoms + bad
what is 1st line chemo in Hodgkins lymphoma
ABVD = anthacristine (eg doxorubicin), bleomycin, vinblastine, dacarbazine
what is 2nd line chemo Hodgkins lymphoma
BEOCOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone)
aside from chemo what other mx for hodkins lymphoma
radio // combined chemo + radio (CMT) // haematopoietic cell transplant
what age group usually get NHL
elderly (75+)
RF NHL
old // white // EBV // FH // history chemo or radio // immunodeficiency // autoimmune disease
symptoms NHL
painless lymph // B symptoms // gastric, bone marrow, lungs, skin, CNS symptoms // weight loss // abdo or testes mass
key differences NHL vs Hodgkins
Hodgkins = pain on alcohol // B symptoms earlier in hodkgins, later in NHL // extra-nodal disease common in NHL
invx NHL
node biopsy // CT chest, abdo, pelvis // FBC + ESR // LDH
staging NHL
ann-arbor (same as hodgkins)
complications hodgkins
aplastic anaemia, neutropenia, thrombocytopenia // SVC obstruction // mets // spinal cord compression
what has better outcome low or high grade NHL
low = better prognosis // high = worse prognosis, good cure rate
what is NHL
any type of lymphoma not hodgkins, can be B or T cell
what type of lymphoma is Burkitt’s
B cell (NHL)
