lymphoma

Question 1

RF Hodgkins lymphoma

Answer 1

HIV, EBV

Question 2

age of Hodgkins lymphoma

Answer 2

30, and 70

Question 3

symptoms Hodgkins lymphoma

Answer 3

painless, asymmetrical lymph nodes (neck) - pain with ALCOHOL // B symptoms - weight loss, itch, night sweats, fever

Question 4

FBC Hodgkins lymphoma

Answer 4

normocytic anaemia // raised eosinophils // raised LDH // (raised ESR = bad)

Question 5

what is seen on lymph biopsy in Hodgkins lymphoma

Answer 5

reid steenberg cells

Question 6

types of Hodgkins lymphoma most –> least common (4)

Answer 6

nodular sclerosing // mixed // lymphocyte predominant // lymphocyte depletes

Question 7

what type of Hodgkins lymphoma has best prognosis

Answer 7

lymphocyte predominant (nodular + mixed also OK)

Question 8

what type of Hodgkins lymphoma has worst prognosis

Answer 8

lymphocyte depletes

Question 9

what symptoms in Hodgkins lymphoma indicate bad prognosis

Answer 9

B symptoms: fever 38+ // night sweats // weight loss >10% in 6 months

Question 10

what staging system is used for Hodgkins lymphoma and what is stage I–>IV

Answer 10

Ann-Arbor // I = single node // II = 2 or more lymph nodes same side of diaphragm // III = lymph nodes both side of diaphragm // IV = spread beyond lymph

Question 11

what does stage A or B in Hodgkins lymphoma mean

Answer 11

A = non systemic (maybe itch) // B = B symptoms + bad

Question 12

what is 1st line chemo in Hodgkins lymphoma

Answer 12

ABVD = anthacristine (eg doxorubicin), bleomycin, vinblastine, dacarbazine

Question 13

what is 2nd line chemo Hodgkins lymphoma

Answer 13

BEOCOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone)

Question 14

aside from chemo what other mx for hodkins lymphoma

Answer 14

radio // combined chemo + radio (CMT) // haematopoietic cell transplant

Question 15

what age group usually get NHL

Answer 15

elderly (75+)

Question 16

RF NHL

Answer 16

old // white // EBV // FH // history chemo or radio // immunodeficiency // autoimmune disease

Question 17

symptoms NHL

Answer 17

painless lymph // B symptoms // gastric, bone marrow, lungs, skin, CNS symptoms // weight loss // abdo or testes mass

Question 18

key differences NHL vs Hodgkins

Answer 18

Hodgkins = pain on alcohol // B symptoms earlier in hodkgins, later in NHL // extra-nodal disease common in NHL

Question 19

invx NHL

Answer 19

node biopsy // CT chest, abdo, pelvis // FBC + ESR // LDH

Question 20

staging NHL

Answer 20

ann-arbor (same as hodgkins)

Question 21

complications hodgkins

Answer 21

aplastic anaemia, neutropenia, thrombocytopenia // SVC obstruction // mets // spinal cord compression

Question 22

what has better outcome low or high grade NHL

Answer 22

low = better prognosis // high = worse prognosis, good cure rate

Question 23

what is NHL

Answer 23

any type of lymphoma not hodgkins, can be B or T cell

Question 24

what type of lymphoma is Burkitt’s

Answer 24

B cell (NHL)

Question 25

what is endemic burkitt’s lymphoma

Answer 25

African - involves maxilla or mandible

Question 26

what is sporadic burkitt’s lymphoma

Answer 26

abdominal tumour more common, more common in HIV

Question 27

what genetic translocation is burkitt’s lymphoma assoc with

Answer 27

c-myc // t8:14

Question 28

what virus is assoc with endemic burkitt’s lymphoma

Answer 28

EBV

Question 29

lymph node biopsy findings burkitt’s lymphoma

Answer 29

starry sky

Question 30

mx burkitt’s lymphoma

Answer 30

chemo

Question 31

common SE burkitt’s lymphoma mx

Answer 31

tumour lysis syndrome (hyperK, phosphate, uric acid // hypoCa // AKI)

Question 32

what is assoc with gastric MALT lymphoma

Answer 32

H.pylori (eradicate if possible)

Question 33

distinctive feature gastric MALT lymphoma

Answer 33

paraproteinaemia