chemo Flashcards
what type of cytotoxic agent is cylophasmamide
alklyating
SE cyclophosphamide
myelosuppresion
what type of chemo is bleomycin + anrthracyclines
cytotoxic antibodies
SE bleomycin
lung fibrosis
SE anthracyclines (eg doxorubicin)
cardiomyopathy
what type of chemo is methotrexate + 5FU
antimetabolites
SE methotrextae
myelosuppression, mucositis, liver fibrosis, lung fibrosis
SE 5-FU
myelosuppression, mucositis, dermatitis
what type of chemo is vincristine/ vinblastine
microtubule
SE vincristine
peripheral neuropathy + paralyctic ileis
SE cisplatin
ototoxic, peripheral neuropathy
what causes neutropenic sepsis
chemo therapy
when does neutropeanic sepsis occur
7-14 days after starting cancer therapy
criteria neutropenic sepsis
neutrophils <0.5 + temp 38 OR clinical sepsis
organism neutropenic sepsis
coag neg, gram +ive eg staph epi
when is prophylaxis for neutropenic sepsis started
if neutrophils expected to drop to <0.5
what is prophylaxis for neutropenic sepsis
fluoroquinolone
mx neutropenic sepsis
piperacillin with tazobactam (Tazocin)
when is mx for neutropenic sepsis started
straight away, do not wait for blood if suspected
if still unwell with neutropenic sepsis after 48 hours what is done
meropenam +/- vanc
if still unwell 4-6 days later with neutropenic sepsis what is done
invx for fungal infection
what can cause tumour lysis syndrome
combination chemo // (can occur independently or with steroids but rare)
what prophylaxis is given for high risk tumour lysis syndrome patients
IV allopurinol or rasburicase
prophylaxis low risk tumour lysis syndrome patients
oral allupirinol
