Lymphoma Flashcards
what is a lymphoma and how will it typically present
neoplastic tumour of lymphoid cells
progressive painless lymphadenopathy, palpable nodes, extranodular masses
what is the epidemiology and associations of hodgekins lymphoma
20% of lymphomas
M>F
20-29 and >60
asso with EBV
how will hodgekins lymphoma present
painless lymphadenopathy +/- ‘B sympto’ (fever, night sweats, weight loss)
alcohol induced pain in nodes
usually 1 node site, contagious spread through lymph nodes
most common subtype of Hodgekins lymphoma
nodular sclerosing
staging of hodgekins lymphoma
Ann-Arbor staging
1 = 1site 2 = 2 sites on same side of diaphragm 3 = 2 of diff sides of diaphragm 4 = extranodular sites (liver/BM)
A = no B sympto B = B sympto
treatment for hodgekins lymphoma
combined chemo (ABVD) - adriamycin, bleomycin, vinblastine, DTIC
radiotherapy may be used alongside - conveys v high risk of breast cancer
which stem cell transplant is most effective for MM/Lymphoma/Leuk
MM/lymphoma = auto leuk = Allo
presentation of non hodgekins lymphoma
80% of lymphomas
painless lymphadonopathy involving multiple sites, no alcohol induced pain
pathology of follicular lymphoma
follicular pattern/nodular appearance
incurable - med survival = 12-15y
pathology of MALT
chronic antigen stim -> lymphomas arise at extra-nodular sites (most commonly due to H.pylori in stomach)
-> epig pain + ulceration
NB Tx of H.Pylori induced MALT - treat H.pylori - goes away
pathology of mantle cell lymphoma
presents in middle aged males
v aggressive (3-5y)
affects LN and GIT
‘angular nuclei’
pathology of diffuse large B cell lymphoma
sheets of large lymphoid cells
v aggressive
Tx = rituximab
pathology of burkitt’s lymphoma
presents as jaw/abdo mass in children/young adults
‘starry sky’ appearance
v aggressive
Tx = rituximab
most common T cell lymphoma
anaplastic large cell lymphoma
features of anaplastic large cell lymphoma
presents in kids/young adults
v aggressive
large epitheliod lymphocytes
Alk-1 expression -> better prognosis
