Bone Marrow Transplant Flashcards

1
Q

How likely are siblings to be an exact match to each other

A

1/4

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2
Q

5 stages of autologous transplant

A

1 - GF injection -> stim stem cell growth
2- CD34+ (stem cell marker) cells collected from BM/ periph blood
3 - conditioning Tx (high dose chemo)
4 -re-infuse stem cells
5 - immune reconstitution

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3
Q

Timeline for acute GVHD

A

normally 2-3w after

but anything <100 days

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4
Q

Pathology of acute GVHD

A

conditioning Tx -> tissue damage -> APC activation -> donor T cell activation -> cellular / inflam markers

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5
Q

3 main organs affected in acute GVHD

A

skin - rash
liver - jaundice + hep
gut - diarrhoea

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6
Q

occurance of chronic GVHD

A

affects 50%

attack all organs

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7
Q

RF for GVHD

A

inc HLA disparity
intense conditioning
inc age
F donor (esp multiparous) to male pt

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8
Q

Tx for GVHD

A

corticosteroids

+/- ciclosporin a (calcineurin inhib)

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9
Q

prevention of GVHD

A

anyone getting a transplant given:
corticosteroids (methotrexate)
+ ciclosporin/tacrolimus

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