Anaemia

Question 1

Causes of Micro Anaemia

Answer 1

FAST

Fe def, AoCD, sideroblastic, Thall

Question 2

causes of normocytic anaemia

Answer 2

blood loss, AoCD, BM failure, renal F, hypothy, haemolysis, preg

Question 3

causes of macro anaemia

Answer 3

FAT RBC

fetus (preg), antifolates, hypoThyroid, Reticulocytosis, B12/folate def, Cirrhosis (alco excess/ liver D)

Question 4

causes of Fe def anaemia

Answer 4

bleeding till proven otherwise
GI bleed - meckel diverticulum, ulcers, polyps
inc utilisation (preg/ growth in kids)
dec uptake (prematurity)
dec absorption (coeliac, post-gastric surg)
intravasc haemolysis (MAHA)

Question 5

causes of AoCD

Answer 5

chronic inf (TB, osteomyelitis)
vasculitis
RA
malig
inflam markers -> dec EPo Receptor prod -> dec EPO

Question 6

Histology of sideroblastic anaemia

Answer 6

ineffective erythropoiesis -> iron loading in bone marrow -> damage due to Fe deposits in tissues

Question 7

what can be seen in the bone marrow in sideroblastic anaemia

Answer 7

ring sideroblasts i BM

Question 8

causes of sideroblastic anaemia

Answer 8

alco excess, lead excess, myelodysplastic disorders

Question 9

Plasma iron studies - dec Fe, inc TIBC, dec ferritin

Answer 9

Fe def

Question 10

Plasma iron studies - dec Fe, dec TIBC, inc ferritin

Answer 10

Aocd

Question 11

Plasma iron studies - inc Fe, dec TIBC, inc ferritin

Answer 11

Chronic haemolysis

haemachromatosis

Question 12

Plasma iron studies - inc Fe, inc TIBC, normal ferritin

Answer 12

pregnancy

Question 13

Plasma iron studies - inc Fe, normal TIBC, inc ferritin

Answer 13

sideroblastic