Leukemia

Question 1

presentation of ALL

Answer 1

in kids
v inc lymphadenopathy + CNS involvement
testicular + thymic enlargement

Question 2

flow cytometry - CD34

Answer 2

precursor/stem cells

Question 3

flow cytometry - CD19

Answer 3

B lymphocytes

Question 4

duration of maintenance in ALL

Answer 4

boys = 3y
girls = 2y

Question 5

who gets AML

Answer 5

adults and <2y

Question 6

auer rods on film

Answer 6

AML

Question 7

flow cytometry - MPO

Answer 7

myeloid cells

Question 8

what affects prognosis in AML

Answer 8

prognosis worse with age

Question 9

large no of differentiated neutrophils on routine bloods

Answer 9

CML

Question 10

sympto of CML

Answer 10

generally unwell, weight loss, bruising, massive splenomeg

Question 11

WCC inc, neutrophils inc, basophils inc, hypocellular BM

Answer 11

CML

Question 12

drug to induce remission in chronic phase of CML

Answer 12

imatinib - induces remission in 45%

= BCR-ABL TKI

Question 13

features of accelerated phase of CML

Answer 13

BM > 10% blasts, inc manifestations, less responsive to Tx

Question 14

features of blast phase of CML

Answer 14

BM > 20% blasts, resembles acute leukaemia

Question 15

symptoms of CLL

Answer 15

symmetrical painless lymphadenopathy, BM failure, FLAWS, hepatic/splenomeg

Question 16

what can CLL progress to

Answer 16

DLBC lymphoma (richter transformation)

Question 17

smear cells on blood film

Answer 17

CLL

Question 18

inc WCC w/ lymphocytosis, dec serum Ig, M>F

Answer 18

CLL

Question 19

what deletions are associated with prognosis in CLL

Answer 19

11q23del = bad

13q14 del = good

Question 20

binet staging of CLL

Answer 20

A = inc WCC, <3 large LNs
B = > 3
C = anaemia + thrombocytopenia