Lymphatics Lecture Flashcards
What did Olaf Rudbeck do and in what year?
First described lymphatics as a system in 1653
What did AT Still document about lymphatics and in what year?
In 1874, emphasized that diagnosis of fascia & treatment of lymphatic system was vital for maintaining health & treating disease
What is important about 1898?
Faculty in Kirksville used early form of X-ray to research the distribution of vascular & lymphatic system
What did Frederic Millard do and in what year?
in 1922, published “Applied Anatomy of the Lymphatics”
3 anatomical components of lymphatic system
Lymph fluid
Lymphatic vessels
Organized lymphatic tissues/organs
Physiologic function of lymphatic system
Major role in numerous homeostatic mechanisms of body (immune, digestive, fluid balance, waste)
Why is it important to maintain homeostasis?
To maintain health (balance of all systems to prevent disease)
Embryological development of lymphatics
In week 5
Mesoderm: lymphatic vessels, lymph nodes, spleen, myeloid tissue
Endoderm: thymus & parts of tonsils
Function of lymphatic system
Maintain fluid balance
Tissue cleansing/purification
Defense
Nutrition
Fluid balance
30L of fluid moves from capillaries to interstitial space per day (10% to lymphatic system)
What happens with fluid overload?
Lymphatic system helps prevent tissue damage by clearing the excess
How does lymphatics play role in purification & cleansing?
Lymph fluid bathes organs & cleanses extracell spaces of particulate matter, toxins, bacteria, etc
Fluid then travels from vessels to nodes & then in venous system
Lymphatics role in defense
Lymph fluid brings toxins/bacteria/viruses into contact w/ organized lymph tissue that have high conc of immune cells
free flow of lymph is necessary for appropriate immune function
Lymphatics role in nutrition (proteins & fats)
Fat absorption via chylomicrons b/c too big to cross capillary junctions
Travel via lacteals in small intestine to larger lymph vessels to thoracic duct & into venous system
Returns proteins to vasculature
What is lymph fluid?
Substances that leak out of arterial capillaries into interstitium get taken up by lymphatic capillaries
Basically, a filtrate of blood
Where does lymph go?
Everywhere except:
Epidermis
Endomysium of muscle
Cartilage
Bone marrow
Flow of lymph in lymphatic vessels
Terminal lymphatics to collecting vessels to afforestation lymph vessels to nodes to efferent lymph vessels to trunks to thoracic duct or right lymphatic duct to venous system
Where does lymph formation begin?
In the interstitial space of tissues w/ initial lymphatics & lymph capillaries
What do the terminal lymphatics become?
Collecting vessels
What are collecting vessels?
Consist of chains of muscular units (LYMPHANGION) that possess 2 leaflet bicuspid valves
How do lymphagnions move lymph?
Contract regularly thru out lymphatic system & move lymph in peristaltic waves due to ANS innervation
What are lymph nodes?
Organized lymphoid tissue dispersed along course of lymph vessels
Superficial LNs
W/ in subcutaneous tissue (cervical, axillary, inguinal)