Lymphatic System Flashcards
Where is the site of lymphocyte production?
Bone marrow
Where are the places that you cannot find lymphatic capillaries? (4)
- Avascular tissue
- CNS
- Portions of the spleen
- Red bone marrow
What is the lacteal?
Lymphatic capillary in small intestine villi that transports digested fats from small intestine into blood
What is the main collecting duct of the lymphatic system?
Thoracic duct
- Starts as cisterna chylli
- The other duct is the RT lymphatic duct in upper RT of body
Flow of lymph
Interstitial fluid
Lymph capillaries
Lymph vessels
Lymphtrunks
Lymph ducts
Subclavian veins
Primary vs secondary lymphoid organs
Primary (cells are immunocompetent): red bone marrow (B cells), thymus gland (T cells)
Secondary (most immune responses): lymph nodes, spleen
Function of thymus gland
Immunity, site of T cell maturation
Function of lymph nodes
Site of proliferation of plasma cells and T cells
Antibodies
Blood proteins produced in response to an antigen
T cells
Attacks antigen, contains major histocompatibility complex (MHC)
What are interferons?
Large cytokine protein, interferes w/ viral replication
Role of natural killer cells
Host rejection
Mast cells
Allergies, wounds, angiogenesis, blood born barriers
CD4 vs CD8 cells
- CD4: T helpers, helps antibodies against antigens
- CD8: cytotoxic T cells
Humoral vs cell-mediated mediators
Humoral: B cells and antibodies, rapid/immediate
Cell-mediated: cytoskines, T helpers/cytotoxic, NK cells, macrophages – delayed/permenant
