Lymphatic Flashcards

1
Q

lymphatic system

A
  • helps immune system emend against infectious agents
  • enlargement of lymphatic vessels is sign that organs are defending body
  • transports and houses lymphocytes and immune cells
  • returns excess fluid to maintain fluid balance
  • lymph is fluid transported in lymph vessels
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2
Q

lymphatic vessels

A
  • tonsils
  • lymph nodes
  • spleen
  • liver
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3
Q

characteristics of lymph

A
  • 10% of fluid entering interstitial apes not reabsorbed into blood capillaries, ~3 laters daily
  • moves passively into lymphatic capillaries due to pressure gradient
  • termed lymph once moved inside lymph vessels
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4
Q

components of lymph

A
  • water, dissolved solutes, and small amount of protein

- pathogens of metaswized cancer cells

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5
Q

lymphatic capillaries

A
  • overlapping endothelial cells
  • one way flaps allows fluid entrance but not exit, pressure allows cells to separate to allow fluid to become lymph
  • anchoring filaments
  • help hold endothelial cells to each other and nearby structures
  • lacteals
  • lymphatic capillaries in GI tract, allow for absorption of lipid-soluble substances from GI tract
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6
Q

movement of lymph into lymphatic capillaries

A
  • increase in hydrostatic pressure in interstitial spaces
  • rises as additional fluid is filtered from blood capillaries
  • pressure pushes fluid into lymphatic capillaries called lumen
  • higher pressure=great volume of fluid entering
  • pressure of lymph causes endothelial cels to close
  • lymph is transported through network of increasing larger vessels
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7
Q

vessel sizes (smallest to largest)

A
  • lymphatic capillaries
  • lymphatic vessels
  • lymphatic trunks
  • lymphatic ducts
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8
Q

lymphatic vessels

A
  • formed from capillaries
  • superficial vessels positioned adjacent to superficial veins
  • Depp vessels next to deeps arteries and veins
  • have valves in their lumen to prevent blood from pooling and prevent back flow in low-pressure system
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9
Q

lymphatic system lacks a pump

A
  • relies on…
  • contraction of skeletal muscles
  • contraction of respiratory pump
  • movement of blood
  • some connect directly to lymph nodes
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10
Q

lymphatic trunks

A
  • fed into by lymphatic vessels in left and right side of body
  • jugular trunks drain lymph from head and neck
  • subclavian trunks drain upper limbs, breast, and superficial thoracic wall
  • bronchomedialstinal trunks drain deeps thoracic structures
  • intestinal trunks drain most abdominal structures
  • lumbar trunks drain lower limbs, abdominopelvic was, and pelvic organs
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11
Q

lymphatic ducts

A
  • largest
  • drained into by lymphatic trunks
  • 2 ducts: right and thoracic
  • convey lymph back into venous circulation of blood
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12
Q

right lymphatic duct

A
  • near right clavicle
  • received lymph from: right side of neck and head, right upper limb, right side of thorax
  • returns lymph to venous circulation
  • junction of right subclavian and right internal jugular veins
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13
Q

thoracic duct

A
  • larger
  • from diaphragm to junction of left subclavian and left jugular veins
  • drains lymph from: left side of neck and head, left upper limb, left side of thorax, abdomen and lower limbs
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14
Q

thoracic duct structure

A
  • has saclike structure at base, cisterna chyli
  • travels superiorly from cisterna chyli
  • lies directly anterior to vertebral bodies
  • passes through aortic opening of diaphragm
  • ascends to left of vertebral body of midline
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15
Q

cisterna chyli

A
  • lipid-rich lymph, chyle, from vessels draining GI tract
  • left and right intestinal and lumbar trunks draining here
  • where all trunk that have chyle meet
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16
Q

primary lymphatic structures

A
  • involved in formation and maturation of lymphocytes

- red bone marrow and thymus

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17
Q

secondary lymphatic structures

A
  • not involved in lymphocyte formation
  • house lymphocytes and other immune cells
  • provide site of immune response initiation
  • lymph nodes, spleen, tonsils, and lymphatic nodules
  • include MALT
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18
Q

red bone marrow

A
  • in spaces between trabecular in spongy bone
  • responsible for hematopoiesis (produce erythrocytes, platelets, granulocytes, and agranulocytes)
  • T-lymphocytes and B-lymphocytes
  • T-lymphocytes migrate to thymus to complete maturation
19
Q

thymus

A
  • bilobed organ in superior mediastinum
  • functions in T-lymphocyte maturation
  • large in infants and young in children
20
Q

why thymus is bigger in children

A
  • grows until puberty
  • begins to regress and is replaced by adipose tissue by process called involution
  • why older adults don’t fight off infection as well due to lower amount of T-cells
21
Q

fused lobes of thymus

A
  • each surrounded by connective tissue capsule
  • trabeculae is fibrous extensions of capsule, dense regular connective tissue
  • subdivided into lobules
22
Q

lobules of thymus

A
  • each has outer cortex and inner medulla
  • both with epithelial tissue
  • cortex has immature T-lymphocytes
  • medulla has mature T-lymphocytes
23
Q

characteristics of secondary lymphatic structures

A
  • house lymphocytes and other immune cells
  • lymphatic cells enmeshed in reticular connective tissue matrix
  • organized into lymphatic organs and lymphatic nodules
  • capsule component or dense irregular connective tissue
  • encapsulated: have complete CT capsule
  • unencapsulated: incomplete or absent capsule
24
Q

lymph nodes

A
  • small, round, oval, encapsulated structures
  • along pathways of lymph vessels
  • filter lymph and remove unwanted substances
  • located deep and superficially
  • typically in clusters
  • when active can be swollen, palpable, and sore
25
Q

afferent lymphatic vessels

A
  • bring lymph into lobe
26
Q

efferent lymphatic vessels

A
  • draines node

- originates at hilum

27
Q

lymph node capsule

A
  • seemed internal extension into to, trabeculae

- subdivided node into components called nodules

28
Q

outer lymph node cortex

A
  • composed partly of lymphatic nodules
  • has reticular fibres
  • support germinal center
  • houses proliferating B-lymphocytes and some macrophages
  • has outer region called mantel zone
  • has T-lymphocytes, macrophages and dendritic cells
  • cortical sinus are tiny open channels lined my macrophages
29
Q

inner lymph node medulla

A
  • connective tissue fibres, medullary cords
  • supports strands of B-lymphocytes, T-lymphocytesm and macrophages
  • lead to sinuses
  • medullary sinus is tiny open channels lines with macrophages
30
Q

lymph flow through lymph nodes

A
  • enters node through afferent lymphatic vessels
  • makes was though lymphatic node sinuses
  • lymph always monitored for presence of foreign material
  • macrophages remove foreign debris from lymph
  • lymph exits node through efferent vessel
  • may enter nearby lymph node in cluster
  • if lymphocyte contracts foreign substance an immune response is generated and lymphocytes undo cell division especially in germinal centres
  • some remaining lymph in node
  • others transported in lymph and blood to reach areas of infection
31
Q

swollen lymph nodes

A
  • become tender with infection
  • sign that lymphocytes proliferating and fighting infection
  • can palpate swollen superficial lymph nodes
32
Q

spleen characteristics

A
  • largest lymphatic organ
  • in left upper abdominal quadrant
  • posterolateral aspect convex and rounded
  • concave anteromedial dodger that contain hilum where blood vessels and nerves enter
33
Q

spleen

A
  • supplied by splenic arteries
  • drained by splenic valve
  • surrounded by connective tissue capsule
  • trabeculae extending into organ
  • subdivided spleen into red and white pulp
34
Q

white pulp of spleen

A
  • clusters of T- and B-lymphocytes and macrohphages
  • contains central artery
  • lymphocytes suspended on reticular fibres
  • lymphatic function
35
Q

red pulp of spleen

A

has erythrocytes, platelets, macrophages, and B-lymphocytes

  • cells in reticular CT, forming splenic cords
  • has splenic sinusoids that have permeable capillaries so blood can exit easily
  • splenic sinusoids drain to small venues leading into splenic vein
  • platelet reservoir to re-enter blood as needed
36
Q

splenic blood flow

A
  • enters splenic artery, splenic arterioles, then into central artery
  • continues through sinusoids of red pulp
  • red pulp macrophages phagocytize (bacteria, foreign debris, old/defective erythrocytes and platelets)
  • re-enters red pulp sinusoids
  • then through venues and out splenic vein
  • PALS is mostly T-cells
37
Q

tonsils

A
  • in pharynx
  • hemicapsultaed
  • help protect against foreign substances inhaled/ingested
  • have invaginated tonsillar crypts to increase surface area to trap material
  • have lymphatic nodules some with active germinal centers
38
Q

3 types of tonsils

A
  • pharyngeal
  • palatine
  • lingual
39
Q

pharyngeal tonsils

A
  • 1 in posterior all of nasophynx

- when enlarged, termed adenoids

40
Q

palatine tonsils

A
  • 2 in posterolateral oral cavity
41
Q

lingual tonsils

A
  • several along posterior 1/3 of tongue
42
Q

lymphatic nodules

A
  • small clusters of lymphatic cells with come extracellular matrix, not completely surrounded by CT capsule
  • scattered nodules termed diffuse lymphatic tissue
  • in every body organ
  • defend against infection
  • sometimes group together to form larger structures (ex MALT)
43
Q

MALT

A
  • mucosa-associated lymphatic tissue
  • in gastrointestinal, respiratory, genital, and urinary tracts in lamina properia of mucosa
  • defend against foreign substances
  • prominent in small intestines, especially ileum
  • peters patches, found here, once anything gets past this it goes into blood stream
  • large collection of lymphatic nodules