Luteal Phase Deficiency

Question 1

clinically detected LPD defined as

Answer 1

luteal phase <= 10

Question 2

conditions associated with LPD

Answer 2

conditions that disrupt normal GnRH and LH pulsatility (eating disorders, excessive exercise, weight loss, stress, obesity, PCOS, thyroid d/o, hyperprolactinemia)

Question 3

MOA of hyperprolactinemia on LPD

Answer 3

prolactin may inhibit GnRH secretion directly by acting on GnRH neuronal PRL receptors or indirectly by increasing hypothalamic dopamine and opioid peptide levels