Lupus Flashcards
What type of hypersensitivity is Lupus?
Type 3
What immune cells are involved in lupus?
B cells
What antibodies are involved in SLE?
ANA Anti-dsDNA Anti-smith Anti-cardiolipin Anti-Ro
What is the pathology of SLE?
B cells produce autoantibodies
Antinuclear antibodies
Widespread immune complex deposition in body
What classification is used for SLE?
SLICC
- Systemic lupus international collaborative clinical criteria
What is requirements for diagnosis by SLICC?
1 clinical sign + 1 lab sign and >3 of the following
SKIN
- Skin rash
- > butterfly common
- > bullous lupus
- > discoid rash
- Non scarring alopecia
- Oral nasal ulcers
MSK
- Synovitis
- Serositis
URINALYSIS
- Proteinuria
- Red cell casts
HAEMATOLOGY
- Haemolytic anaemia
- Leucopenia
- Thrombocytopenia
Apart from autoantibodies, what other lab findings can be used in diagnosis?
Low compliment
+ve coombs test
What is a hallmark of SLE?
Membraneous glomerulonephritis
What is gold standard test?
Fluorescent microscopy
What antibodies will show homogenous fluorescent microscopy?
Anti-dsDNA
What antibodies show speckled fluorescent microscopy?
Anti-Ro
What antibodies show nucleolar fluorescent microscopy?
Nuclear specific
What drugs may cause drug induced lupus?
Quinidine
Hydrosalazine
Treatment of lupus?
NSAIDs
Immunosuppression
