Lupus

Question 1

What is the etiology of SLE?

Answer 1

genetics, hormonal, environment

Question 2

What drugs induce Lupus (DILE)?

Answer 2

Methimazole, Propylthiouracil, Methyldopa, Minocycline, Procainamide, Hydralazine, Anti-TNF agents, Terbinafine, Isoniazid, Quinidine

-My Pretty Malar Marking Probably Has A Transient Quality

Question 3

What are the key labs for diagnosis of lupus?

Answer 3

Anti-Nuclear Antibody (ANA), Anti-Double-stranded DNA (Anti-dsDNA), Anti-Smith Antibody (Anti-SM), Antiphospholipid antibody

Question 4

What pharmacologic treatments are there for Lupus?

Answer 4

Hydroxychloroquine, NSAIDs, Glucocorticoids, Immunosuppressants, biologics

Question 5

What is the G6PD deficiency?

Answer 5

x-linked that causes RBCs to prematurely breakdown

Question 6

What is the max dose of naproxen?

Answer 6

1250 mg

Question 7

What is the max dose of ibuprofen?

Answer 7

3200 mg

Question 8

What are the topical glucocorticoids?

Answer 8

Low potency: fluocinolone valerate & hydrocortisone
Mid potency: triamcinolone acetonide & betamethasone valerate
High potency: Clobetasol

Question 9

When are immunosuppressants indicated & what are they?

Answer 9

more severe disease
- methotrexate, azathiopurine, cyclophosphamide, mycophenolate
-monitor for TPMT deficiency

Question 10

What biologics are indicated for lupus?

Answer 10

Belimumab, Rituximab, Anifrolumab

Question 11

What medication is indicated for lupus nephritis?

Answer 11

Mycophenolic acid