Lung Cancer

Question 1

What treatment is indicated for extensive stage SCLC?

Answer 1

cisplatin either w etoposide or irinotecan +atezolizumab/durvalumab
-no radiation unless symptoms (palliative)

Question 2

What are toxicities experienced with platinum based chemo?

Answer 2

-N/V
-nephrotoxicity, ototoxicity (hearing loss), neuropathy

Question 3

What is the next line of therapy for metastatic SCLC whom have progressed after platinum-based therapy?

Answer 3

Pembrolizumab regardless of PD-1 status

Question 4

What treatment options are indicated in unresectable NSCLC?

Answer 4

-radiation
paclitaxel/gemcitabine/docetaxel + cisplatin + durvulamab

Question 4

What are the treatment options in metastatic NSCLC w/mutation?

Answer 4

Osimertinib (EGFR)
Dabrafenib/Trametinib (BRAF) -fevers
Sotorasib (KRAS)

Question 5

What is the first line treatment for mutation negative metastatic squamous NSCLC?

Answer 5

Pembrolizumab + carboplatin + paclitaxel

Question 6

What labs need to be monitored in patients recieving immunotherapy?

Answer 6

TSH & Free T4
CBC/ w diff
CMP
amylase & lipase

Question 7

What would be the preferred treatment regimen for someone with limited stage SCLC?

Answer 7

cisplatin + etoposide
-radiation
-no maintenance therapy

Question 8

What would be the preferred regimen for someone with resectable NSCLC with no mutations? (squamous & non-squamous)

Answer 8

non-squamous= cisplatin + pemetrexed
squamous= cisplatin + gemcitabine/docetaxel

Question 9

What is the first line treatment for NSCLC metastatic squamous cell?

Answer 9

pembrolizumab + carboplatin + paclitaxel (or nab-paclitaxel)

Question 10

What is the first line treatment for non-squamous metastatic NSCLC mutation negative?

Answer 10

carboplatin + Pemetrexed + Pembrolizumab