Immunology Flashcards
What monocolonal antibodies bind HER2?
Trastuzumab
Pertuzumab -inhibits dimerization of HER2
What monoclonal antibodies bind the EGF receptor?
Cetuximab
Panitumumab
What is the nomenclature with monoclonal anitbodies?
mouse = -o
chimeric = -xi
humanized = -zu
fully human = -u
What is the two tiered targeting mechanism of antibody therapy as compared to small molecule kinase inhibitors?
-antibodies bind to surface of tumor cells and inhibit the function
-activates the ADCC lead to differential therapeutic outcomes
What medications target CD20/BCR?
Rituximab
Ofatumumab
-treat B-cell lymphomas
What is the target of Blinatumomab?
targets T-cell CD3 / CD19 antigen on B-cell cancer
-BiTE therapy
What is the target of Mosunetuzumab?
targets T-cell CD3 / CD20 antigen on non-hodgkin lymphoma
-BiTE therapy
What does Teclistamab target?
CD3 on T cells / BCMA (B-cell maturation antigen) for multiple myeloma
What is type of drug is Bevacizumab?
binds VEGF ligand to inhibit solid tumor growth
-Ramucirumab also in this class but binds receptor
What does Taquetamab target?
CD3 on T cells / GPCR5D on multiple myeloma cells
What medications inhibits CD20 on B cells?
Rituximab, Ofatumumab
What medication targets CD38 on B cells?
Daratumumab
What are the antibody drug conjugates?
T-DM1 (Ado-Trastuzumab Emtansine)
-binds to HER2/Neu receptor
-modified tubulin inhibitor
-thrombocytopenia, hepatotoxicity
What is the mechanism of action for Ipilimumab (Yervoy)?
binds the CTLA-4 receptor and reverses the CTL (Cytotoxic T lymphocytes) inhibition reactivating T cells
What is the mechanism of action for Pembrolizumab (Keytruda)?
mab that binds to PD-1 (expressed on T cells) and blocks interaction with PD-L1 found on cancer cells allowing for more killing of tumor cells
