Lower GI disorders Flashcards
What are some common lab findings in celiac sprue?
Iron deficiency, folate deficiency, vitamin D deficiency
What labs are used to diagnose Celiac disease?
- IgA anti-tissue transglutaminase antibody *** first line
- endomysial antibody
- gold standard: histo assessment of distal duodenum - villous flattening/atrophy
Lab markers of inflammatory bowel disease?
Fecal lactoferrin and calprotectin - surrogate markers for bowel inflammation and may help distinguish IBD and IBS
What lab finding helps specify that UC may be the cause of IBD?
P-ANCA
First line therapy in Ulcerative colitis?
Sulfsalazine
How often should patients with UC have colonoscopies to screen for colon cancer?
every 2-5 years
Initial testing of chronic diarrhea?
- CBC
- CRP
- ESR
- BMP
- LFT
- stool cultures
- c diff toxin
- O and P
What colonoscopy finding is common for crohns?
- skip lesions, cobblestoning, ulcerations, strictures
Presence of antibodies to E coli outer membrane porin and saccharomyces is suggestive of which disease?
Crohn’s
Treatment for campylobacter
azithromycin
Treatment of shigella
- quinolone in adults
- TMP-SMX in children
Treatment of traveler’s diarrhea
- azithromycin
- loperamide is a good adjunct to abx
Treatment of cholera
- rehydration
- doxycycline
Leading cause of infectious diarrhea in children in US
rotavirus
leading cause of foodborne disease in US and gastroenteritis in US adults
norovirus
