Lower GI disorders Flashcards
What are some common lab findings in celiac sprue?
Iron deficiency, folate deficiency, vitamin D deficiency
What labs are used to diagnose Celiac disease?
- IgA anti-tissue transglutaminase antibody *** first line
- endomysial antibody
- gold standard: histo assessment of distal duodenum - villous flattening/atrophy
Lab markers of inflammatory bowel disease?
Fecal lactoferrin and calprotectin - surrogate markers for bowel inflammation and may help distinguish IBD and IBS
What lab finding helps specify that UC may be the cause of IBD?
P-ANCA
First line therapy in Ulcerative colitis?
Sulfsalazine
How often should patients with UC have colonoscopies to screen for colon cancer?
every 2-5 years
Initial testing of chronic diarrhea?
- CBC
- CRP
- ESR
- BMP
- LFT
- stool cultures
- c diff toxin
- O and P
What colonoscopy finding is common for crohns?
- skip lesions, cobblestoning, ulcerations, strictures
Presence of antibodies to E coli outer membrane porin and saccharomyces is suggestive of which disease?
Crohn’s
Treatment for campylobacter
azithromycin
Treatment of shigella
- quinolone in adults
- TMP-SMX in children
Treatment of traveler’s diarrhea
- azithromycin
- loperamide is a good adjunct to abx
Treatment of cholera
- rehydration
- doxycycline
Leading cause of infectious diarrhea in children in US
rotavirus
leading cause of foodborne disease in US and gastroenteritis in US adults
norovirus
Most common cause of bacterial diarrhea in adults in us
salmonella
Is prophylaxis for travelers diarrhea recommended?
no
most common offending antibiotic for pseudomembranous enterocolitis
amoxicillin
Treatment of diverticulitis outpatient?
cipro/flagyl and clear liquids
What is the most frequent internal neoplasm in the US?
colon cancer
What you screen for in an adult that suddenly develops constipation
colon cancer
