long term control of blood pressure Flashcards
Where is renin produced
From the juxtaglomerular cells of the kidney
What causes production of renin
- Sypmpathetic activation of juxtaglomerular apparatus
- Decreased distension of the afferent arterioles
- Decreased NA/CL through the ubule
What releases renin
The macula densa
What does high blood pressure mean for filtration at the kidney
More Na/Cl being delivered so more filtration
What does low blood pressure cause at the kidney
Low pressure detected by reduced delivery of Na/Cl at the macula densa which signals the release of renin
What is the function of renin
Converts inactive angiotensinogen into angiotensin I
What converts angiotensin I into angiotensin II
ACE - angiotensin converting enzyme
Whtat does angiotensin II cause
- Stimulates release of aldosterone from adrenal cortex which causes increased sodium reabsorption in the loop of henle
- Increases ADH from the pituitary which increases water permeability at the collecting duct and causes increased plasma volume
- Is a vasoconstricter and causes increased TPR
Where is ADH produced and then released from
Produced in the hypothalamus and then released from the posterior pituitary
Where are ANP and BNP rproduced
Myocardial cells in the atria and ventricles
What triggers ANP and BNP release
Increased Distension in the atria and ventricles which is a sign of increased mean arterial pressure
What do ANP and BNP cause
Increase excretion of sodium and inhibit the release of renin - therefore causing decreased MAP
