Local Anesthetics Flashcards
1
Q
what are the “ester” LAs?
A
- procaine
- tetracaine
- cocaine
2
Q
where are amide LAs metabolized?
A
liver
3
Q
where are ester LAs metabolized?
A
plasma (esterase)
4
Q
what does too much prilocaine cause?
A
methemoglobinemia
5
Q
what is the mechanism of action of LAs?
A
prevent the generation of nerve impulses by interferring with sodium transport into the neuron
6
Q
what must happen to LAs before they can penetrate tissue membranes?
A
must be non-ionized (free base form)
7
Q
what is it difficult to anesthetize a person with an acute infection?
A
inflamed tissue has a lower than normal pH, which decreases the amount of non-ionized form available to penetrate
