Adrenergics Flashcards
what do receptor blockers do?
alpha or beta adrenergic drugs such as prazosin or propranolol act by competitive inhibition of postjunctional adrenergic receptors
what does reserpine do?
antiadrenergic drug that depletes NE by inhibiting reuptake
what does guanethidine do?
antiadrenergic drug that inhibit the release of catecholimines
what does alpha methyldopa do?
antiadrenergic drug that acts centrally as a false neurotransmitter which gets taken up into storage vesicles and released with NE, thus decreasing sympathetic activity
what does clonidine do?
antiadrenergic drug that stimulates alpha 2 receptors in CNS with a resulting decrease in sympathetic outflow
what are the durgs that are indirect acting sympathomiimetic drugs?
amphetamine tyramine ephedrine TCAs cocaine MAOIs
which indirect acting sympathomimetic drugs act by stimulating the release of stored NE?
amphetamine, tyramine, and ephedrine
which indirect acting sympathomimetic drugs act by blocking reuptake of NE?
TCAs
cocaine
which indirect acting sympathomimetic drugs act by blocking enzymatic destruction?
MAOIs
what is epi reversal?
in the presence of an alpha blocker (usually prazosin) epi causes dec in BP rather than an inc bc beta mediated vasodilation predominates
what is a vagal reflex?
injection of a pressor does of NE may result in dec HR due to activation of baroreceptors which stimulate vagal reflex to reduce HR. Vagal reflex is blocked by atropine
what is the result of alpha-1 receptor stimulation?
vasoconstriction, urinary retention, mydriasis
*inc in BP
what is the result in beta receptor stimulation?
inc HR (B1)
bronchodilation (B2)
vasodilation (B3)
what is the result of an alpha 1 block?
vasodilation
what is the result of a beta block?
dec HR (B1) bronchconstriction (B2)
