General Principles of Drug Action

Question 1

what does a pharmacologic agonist do?

Answer 1

binds to specific receptor and produces a response

Question 2

when comparing drugs with respect to intensity of response, the drug taht produces the greatest max effect is the one with the highest ____

Answer 2

efficacy

Question 3

if drug A has a greater efficacy that drug B, then drug A ____

Answer 3

is capable of producing a greater max effect than drug B

Question 4

A drug with a high LD 50 and a low ED 50 has a …

Answer 4

high therapeutic index and is , therefore relatively safe

Question 5

the ratio of the median lethal dose (LD50) to the median effective dose (ED 50 is the ….

Answer 5

therapeutic index

Question 6

what is the therapeutic index of a drug?

Answer 6

the lethal dose for 50% of animals to the effective dose for 50% of animals

Question 7

the phenomenon in which two drugs produce opposite effects on a physiologic system bu t do not act at the same receptor site is …

Answer 7

phisiologic antagonism

Question 8

epi antagonizes the effects of histamine by …

Answer 8

producing physiologic actions opposite to that of histamine

Question 9

interaction btw nitro and epi is what type of antagonism?

Answer 9

physiologic

Question 10

what the combined action of two drugs is greater than the sum of their individual actions, this is….

Answer 10

synergism

Question 11

what is the reaction of a drug that is least predictable?

Answer 11

idiosyncrasy

Question 12

idosyncrasies to drugs are related to what?

Answer 12

genetic factors

Question 13

according to the theory that agaonists and antagonist occupy the same receptor site, an effective antagonist should exhibit ….

Answer 13

no intrinsic activity and high affinity