Local and extrinsic controls of peripheral circulation Flashcards

1
Q

Control of peripharl vascular resistance includes?

A

Instrinsic controls: local paracrine signaling or metabolic products

Extrinsic controls: nerual and hormonal

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2
Q

Main method of delivering more oxygen to myocardial tissue during exercise?

A

Increasing coronary blood flow by incrinsic, local autoregulatory control

Heart already extracts a large amount of oxygen from blood

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3
Q

Effect of CO2 on cerebral circulation

A

Potent vasodilator

Main control (intrinsic autoregulatory)

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4
Q

What mechanism controls blood flow in cutaneous circulation?

A

Neural mechanisms (sympathetic division of ANS)

Mediator is norepi

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5
Q

Under what pressure(s) does blood flow change linearly with BP?

A

Under 50 mmHg and over 150 mmHg

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6
Q

Reactive hyperemia

A

Occurs after tissue blood supply is blocked for a short time - after unblocking - blood flow increases immediately 4-7 times normal

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7
Q

active hyperemia

A

Occurs when tissue metabolic rate increases, that immediately increases the rate of blood flow through tissue (i.e. exercise, GI gland during a hypersecretory period, or the brain during increased mental activity)

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8
Q

What are the substrates for endothelial-derives NO synthase?

A

L-Arg and O2 and reduction of inorganic nitrate

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9
Q

Myogenic autoregulation

A
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10
Q

Hormonal vasoconstrictors

A
  1. Angiotensin II
  2. Vasopressin (ADH)
  3. Serotonin
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11
Q

What causes dilation of arterioles and constriction of venules?

A

Bradykinin and histamine

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12
Q

What is the normal coronary blood flow in a healthy adult?

A

5% of CO or ~250 ml/min,.

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13
Q
A
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14
Q
A
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