Lipoprotein metabolism

Question 1

Answer 1

Peak II - correlates with VLDLs

Question 2

A patient with ApoC-II deficiency would MOST likely present with:

Answer 2

b) Elevated chylomicrons

Question 3

PCSK9’s physiological role involves:

Answer 3

Degrading internalized LDL receptors

Question 4

In familial hypercholesterolemia, homozygotes have cholesterol levels between:

Answer 4

500-800 mg/dL

Question 5

Macrophage scavenger receptors contribute to atherosclerosis by:

Answer 5

Continuing uptake despite cellular cholesterol overload

Question 6

What is the main function of ABCA1 in reverse cholesterol transport?

Answer 6

Facilitating lipid transfer to lipid-poor ApoA-I

Question 7

In what pathway do chylomicrons enter circulation through the thoracic duct?

Answer 7

Exogenous pathway

Question 8

Answer 8

Increased susceptibility to oxidative modification

Question 9

If a patient has normal LDL-C but elevated ApoB, which of the following is most likely:

Answer 9

b) Presence of small, dense LDL particles

Question 10

What activates lipoprotein lipase?

Answer 10

ApoC-II

Question 11

VLDL is synthesized in the liver in respone to what?

Answer 11

Excess dietary carbohydrates and sugars