LLC Flashcards

1
Q

LLC , quel cellule tumoral quel envahissement

Dg+

A

Lymphoprolif le + fq.
Accumulation maligne monoclonal de LB MATUREs
Infitrant MO, sang et gg
Evolution lent>3 mois

Dg: hyperlympho>5G/L
Et IMMUNOPHENOTYPAGE CD19+, cd20+, 23+, cd5

SCORE MATUTES >=4
Cd5, cd23+, f.c7- cd79+, ig surface faiblement exprimé

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2
Q

Comment compter les aires gg LLC

A
Sus axillaire bilat=1
Acillaire =1
Unguinal=1
Hmg=1
Smg=1
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3
Q

Bilan pronostic et infication de traitement selon une classification pour la LLC

A

BINET

P593

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4
Q

Specificité frottis sg LLC

A

Ombre gumprecht, lymphocutes normaux, petit

Cytoplasme reduit, chromatine mure et dense

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5
Q

F mauvais pronostic LLC

A
Age, comorbidite
Cytogenetique : del11q, del17p, mut53
Tps doublement lymphocyte<12 mois
Cd38+
Expression kinase ZAP70+
Thymidine kinase augmenté ds serum
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6
Q

Complication LLC

A

P594

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