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Histology > Liver, Pancreas and Biliary Tract > Flashcards

Liver, Pancreas and Biliary Tract Flashcards

1
Q

What are sinusoids

A

Specialised blood vessels

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2
Q

What are the principle cells of the liver

A

Hepatocytes

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3
Q

Describe the liver

A

Portal tract

Hepatocytes arranged in cords with intervening sinusoids

Central veins

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4
Q

What does the portal tract contain

A

Portal veins

Arteries

Bile ducts

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5
Q

What are classic lobule

A

Area drained by one central hepatic lobule

Artificial construct

Roughly hexagonal

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6
Q

What is the acinus

A

Architectural concept based around the blood supply rather than drainage - diamond

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7
Q

Why are all hepatocytes not equal

A

Closest to edge of lobule and central artery receive greater flow of blood as blood veins out in

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8
Q

Describe hepatocytes

A

Principle functional cells of liver

Polyhedral epithelial cells

Abundant mitochondria

Larger central spherical nucleus

Prominent nucleoli

May be binucleate

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9
Q

What are the surfaces of the hepatocytes

A

3

Sinusoidal 70%
- permits exchange of material with blood (space of Disse)

Canalicular 15%
- permits excretion of bile

Intercellular 15%

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10
Q

Describe the space of Disse

A

Contains stem cells - etocells

Contains reticulin fibres

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11
Q

Describe sinusoids

A

Highly specialised blood vessels

Thin discontinuous fenestrated endothelium

No basement membrane

Contains scattered Kupffer cells

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12
Q

Describe Kupffer cells

A

Phagocytic cells

Derived from blood monocytes

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13
Q

Describe the intrahepatic biliary tree

A

Canaliculi (lie between individual hepatocytes)

Bile ductules

Trabecular ducts

Bile ducts

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14
Q

What are the bile ducts lined by

A

Simple cuboidal-columnar epithelium resting on a basement membrane

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15
Q

What is the epithelium of the gallbladder

A

Simple columnar epithelium

Beneath is a specialised mucosa

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16
Q

Describe the specialised mucosa of the gallbladder

A

Increase SA - adapted for water and salt absorption

Microvilli - thrown into folds

17
Q

Describe the exocrine pancreas

A

Synthesise and secrete enzymes bicarbonate-rich fluid into the duodenum

Surrounded by poorly defined capsule with septa dividing gland into lobules

Epithelial cells arranged in acini

18
Q

Describe acinar cells

A

Epithelial

Pyramidal shape

Basally - rich in RER

Apically - zymogen granules - precursors for enzymes

19
Q

What do acinar cells drain into

A

Centroacinar cells

Intercalated ducts

Interlobular ducts

Main pancreatic ducts

20
Q

What is the interlobular duct epithelium

A

Cuboidal

21
Q

What is the pancreatic duct epithelium

A

Histology (17 decks)

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