Liver general Flashcards
Functions of the liver
Glucose and fat metabolism
Detoxification and excretion
Protein synthesis
Defence against infection (reticulo-endothelial system)
Give examples of chemicals in the body which are detoxified and excreted
Biilirubin
Ammonia
Drugs/hormones/pollutants
Example of proteins synthesised by the liver
Albumin
Clotting factors
Types of liver injury
Acute
Chronic
What can result from acute liver injury
Recovery
Liver failure
Acute causes of liver failure
Viral (A, B, EBV) Drugs, Alcohol Vascular Obstruction Congestion
Chronic causes of liver failure
Recovery
Cirrhosis
Liver failure (varies, hepatoma)
Presentation of acute liver injury
Malaise, nausea, anorexia
Occasionally jaundice (doesn’t occur with everyone)
Rare:
-Confusion (encephalopathy)
-Bleeding
-Liver pain
-Hypoglycaemia (since liver breaks down glycogen to glucose, also the liver is the bodies major glucose store)
Presentation of chronic liver injury
Ascites Oedema (varices) Malaise Anorexia Wasting Easy bruising (since the liver produces clotting factors) Itching Hepatomegaly Abnormal LFTs Rare = Jaundice, Confusion
What are ascites?
Fluid accumulation in the peritoneal cavity
Examples of Liver Function Tests (LFTs)
Serum albumin
Bilirubin
Prothrombin time
Examples of liver biochemistry tests - is this a types of liver function test?
Liver biochemistry tests give NO index of liver function:
Aminotransferases
Alkaline Phosphate
In acute liver disease, what is expected from initial albumin levels?
May be normal
Low albumin is a bad prognostic sign
In LFTs, is bilirubin normally all conjugated or unconjugated?
All unconjugated
What can cause prolonged prothrombin time and what can it be a marker of?
Marker of synthetic function.
Sensitive indicator due to its short half-life for both acute and chronic liver disease.
Longer P time can result from vitamin K deficiency.
What is effect of biliary obstruction on Prothrombin time?
Biliary obstruction leads to low concentration of bile salts
Results in poor absorption of vitamin K and thus deficiency in vitamin K means reduced coagulation and longer prothrombin time
Give examples of amino-transferases that can be measured to assess liver biochemistry
Where are amino-transferases found?
Enzymes are found in hepatocytes and leak into blood with liver cell damage. Aspartate aminotransferase (AST) Alanine aminotransferase (ALT)
Which aminotransferase is more specific to the liver?
ALT - Alanine Aminotransferase
Rise only occurs in liver disease
AST also present in heart, muscle, kidney and brain
In what other cases are Aspartate aminotransferases high, other than liver damage?
Hepatic necrosis
Myocardial infarction
Muscle injury
Congestive cardiac failure
What colour is bilirubin?
Yellow (contributes to colour of bile)
What are bile pigments formed from
Haem portion of Hb when old/damaged erythrocytes are broken down in the spleen and liver
What is the predominant bile pigment?
Bilirubin
What cells break down old or damaged erythrocytes and where are these cell found?
Macrophages
Spleen, bone marrow, liver (Kupffer cells here)
When erythrocytes are ingested by macrophages, what are they initially broken into?
Haem and globin
What is globin broken down into
Amino acids which can be used to generate new erythrocytes in the bone marrow
What is haem broken down into
Biliverdin
Fe2+ (transported to bone marrow to be implemented into new erythrocytes by transporter transferrin)
CO
What happens to biliverdin from haem breakdown?
Biliverdin is reduced by biliverdin reductase into UNCONJUGATED BILIRUBIN (toxic and must be secreted)