GI tract cancers Flashcards
Examples of GI cancers
Oesophageal
Gastric
Colorectal cancer (CRC)
Types of oesophageal cancer
Squamous
Adenocarcinoma
Clinical presentation of oesophageal cancer
Early = no symptoms Late = dysphagia, weight loss, heartburn, Haematemesis (vomiting blood), hoarse voice
Pathophysiology of oesophageal squamous cancer
Tends to be located in the proximal 2/3rds of the oesophagus
Can locally cause pressure on Recurrent Laryngeal nerve
Aetiology of oesophageal squamous cancer
Smoking, alcohol, nitrous amines (BBQ food, tobacco)
Pathophysiology of oesophageal adenocarcinoma
Tends to be located in the distal 1/3rd of the oesophagus.
Can locally cause pressure on recurrent laryngeal nerve
Aetiology of oesophageal adenocarcinoma
Barrett’s oesophagus, obesity
Epidemiology of oesophageal adenocarcinoma
Obese people
Diagnosis of oesophageal cancer
Oesophagoscopy with biopsy
CT/MRI to stage cancer
Treatment of oesophageal cancer
Oesophagectomy with preoperative chemotherapy
Clinical presentation of gastric cancer
Nonspecific: Dyspepsia, weight loss, vomiting, dysphagia and anaemia.
Signs: Epigastric mass, hepatomegaly, jaundice, Troisier’s sign (enlarged left supraclavicular node (Virchow’s node)).
What type of cancer are most gastric cancers
90% are Adenocarcinomas
Most involve pylorus
Aetiology of gastric cancer
Multifactorial and often unknown
H.pylori can double the risk
Smoking is a risk factor
Gastritis and pernicious anaemia
Diagnosis of gastric cancer
Gastroscopy with biopsy
CT/MRI to stage cancer
Treatment of gastric cancer
Gastrectomy (partial or total) with preoperative chemo