GI tract cancers Flashcards

1
Q

Examples of GI cancers

A

Oesophageal
Gastric
Colorectal cancer (CRC)

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2
Q

Types of oesophageal cancer

A

Squamous

Adenocarcinoma

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3
Q

Clinical presentation of oesophageal cancer

A
Early = no symptoms
Late = dysphagia, weight loss, heartburn, Haematemesis (vomiting blood), hoarse voice
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4
Q

Pathophysiology of oesophageal squamous cancer

A

Tends to be located in the proximal 2/3rds of the oesophagus

Can locally cause pressure on Recurrent Laryngeal nerve

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5
Q

Aetiology of oesophageal squamous cancer

A

Smoking, alcohol, nitrous amines (BBQ food, tobacco)

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6
Q

Pathophysiology of oesophageal adenocarcinoma

A

Tends to be located in the distal 1/3rd of the oesophagus.

Can locally cause pressure on recurrent laryngeal nerve

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7
Q

Aetiology of oesophageal adenocarcinoma

A

Barrett’s oesophagus, obesity

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8
Q

Epidemiology of oesophageal adenocarcinoma

A

Obese people

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9
Q

Diagnosis of oesophageal cancer

A

Oesophagoscopy with biopsy

CT/MRI to stage cancer

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10
Q

Treatment of oesophageal cancer

A

Oesophagectomy with preoperative chemotherapy

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11
Q

Clinical presentation of gastric cancer

A

Nonspecific: Dyspepsia, weight loss, vomiting, dysphagia and anaemia.
Signs: Epigastric mass, hepatomegaly, jaundice, Troisier’s sign (enlarged left supraclavicular node (Virchow’s node)).

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12
Q

What type of cancer are most gastric cancers

A

90% are Adenocarcinomas

Most involve pylorus

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13
Q

Aetiology of gastric cancer

A

Multifactorial and often unknown
H.pylori can double the risk
Smoking is a risk factor
Gastritis and pernicious anaemia

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14
Q

Diagnosis of gastric cancer

A

Gastroscopy with biopsy

CT/MRI to stage cancer

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15
Q

Treatment of gastric cancer

A

Gastrectomy (partial or total) with preoperative chemo

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16
Q

Clinical presentation of Colorectal cancer (CRC) of left side

A

Most are left side of colon: rectal bleeding, increasing symptoms of intestinal obstruction (bowel habit, coliky pain).

17
Q

Clinical presentation of Colorectal cancer (CRC) of right side or caecum

A

Right side + ceacum: iron deficiency anaemia, mass in right iliac fossa. Non specific symptoms.

18
Q

Pathophysiology of CRC

A

Adenomatous polyps develop over time, though begnin they can become malignant through activation of oncogenes and inactivation of tumour suppressor genes. Increased no. of polyps increases chance of malignancy.
5% due to genetic syndromes:
HNPCC: accelerated progression of adenoma to CRC, >50% develop CRC after 40.
FAP: APC gene, >100 polyps develop in teenage years, 100% lifetime risk of CRC. (Both have increased risk of extracolonic malignancy).

19
Q

What are polyps

A

abnormal tissue growths that most often look like small, flat bumps or tiny mushroomlike stalks. Most polyps are small and less than half an inch wide. Polyps in the colon are the most common

20
Q

CRC risk factors

A
Smoking
Increased Age
Family hx
Inflammatory Bowel Disease
Streptococcus bovis bacteraemia
(Western diet)
Congenital polyposis syndromes
Genetic predisposition
21
Q

Epidemiology of CRC

mean diagnosis and how common

A

Mean diagnosis age 60-65
3rd most common malignancy
2nd biggest killer cancer

22
Q

Diagnosis of CRC

A

DRE (Digital Rectal Exam), colonoscopy with biopsy

Faecal occult blood test for screening only

23
Q

What does treatment of CRC depend on

A

Extent of the disease

24
Q

Complications of CRC

A

Local invasion and distant metastases, often liver and lung

Obstruction

25
Q

Give examples of Congenital polyposis syndromes that are risk factors for CRC

A

Juvenile polyposis syndrome

Peutz-Jeghers syndrome

26
Q

Give examples of genetic predispositions that are risk factors for CRC

A

Familial adenomatous polyposis (FAP)

Hereditary non-polyposis colorectal cancer

27
Q

What is CRC

A

Cancer of the colon and rectum

3rd most common cancer and usually an adenocarcinoma on histology

28
Q

Conservative treatment of CRC

A

Patient education and referral to Macmillan nurses

29
Q

Medical treatment of CRC

A

Chemotherapy (oxliplatin, folinic acid and 5-fluorouracil is most common regime)
Radiotherapy also used

30
Q

Surgical treatment of CRC

A

Surgical resection is usually treatment of choice

31
Q

Investigations of CRC

A

Bowel Cancer Screening Programme - faecal occult blood test in men and women aged 60-69 years
Bloods - FBC for iron deficiency anaemia and carcinoembryonic antigen (CEA) tumour marker
Endoscopy - colonoscopy/sigmoidoscopy
Imaging - double contrast barium enema study ‘apple core’ sign; virtual colonoscopy

32
Q

*Describe the Dukes staging system

A

Stage A:
Confined to muscularis mucosa (90% 5-year survival)
Stage B:
Extends through muscularis mucosa (65% 5-year survival)
Stage C:
Lymph node involvement (30% 5-year survival)
Stage D:
Distant metastases (<10% 5-year survival)

33
Q

Describe the TNM system

A
T = Carcinoma in situ:
T1 - Submucosa invaded
T2 - Muscularis mucosa inavded
T3 - Tumour has invaded subserosa but other organs have not been penetrated
T4 - Adjacent organs inavded
N1 = Metastatic spread to 1-3 regional lymph nodes
N2 = Metastatic spread to at least 4 regional lymph nodes
M0 = No distant metastases present
M1 = Distant metastases present