lippincott questions Flashcards
A 43-year-old heavy machine operator complains of seasonal allergies. Which one of the following medi- cations would be most appropriate for management of his allergy symptoms?
A. Cyclizine.
B. Doxylamine.
C. Hydroxyzine.
D. Fexofenadine.
D
Which one of the following statements concerning
H1 antihistamines is correct?
A. Second-generation H1 antihistamines are
relatively free of adverse effects.
B. Because of the established long-term safety of
first-generation H1 antihistamines, they are the
first choice for allergic rhinitis.
C. The motor coordination involved in driving an
automobile is not affected by the use of first-
generation H1 antihistamines.
D. H1 antihistamines can be used in the treatment of
acute anaphylaxis.
E. Both first- and second-generation H1 antihistamines readily penetrate the blood–
brain barrier.
A
Which of the following medications has the most
potential to significantly impair the ability to drive an automobile?
A. Diphenhydramine.
B. Levocetirizine.
C. Fexofenadine.
D. Ranitidine.
A
Which of the following histamine receptor antagonists is known to enter the central nervous system readily and is known to be sedative?
A. Hydroxyzine.
B. Cetirizine.
C. Desloratadine.
D. Loratadine.
E. Fexofenadine.
A
Which of the following statements about histamine receptor antagonists is MOST ACCURATE?
A. Most antihistamines have no antimuscarinic effects.
B. Alpha Adrenergic effects of antihistamines may cause
hypertension.
C. First-generation antihistamines have no sedative
side effects.
D. Because of their cholinergic properties,
antihistamines may not be effective in the relief of
vertigo associated with motion sickness.
E. Headache may be associated with some second-
generation antihistamines.
E
A passenger sitting next to you in a plane boasts that
he was a famous biochemist. He said he carboxylated a sedating antihistamine, and it is now only partially sedating and is a very well-known drug in the market. Which drug is he talking about?
A. Hydroxyzine.
B. Cetirizine.
C. Diphenhydramine.
D. Doxylamine.
E. Cyproheptadine.
B
Which of the following is an H1-receptor antagonist that also has serotonin receptor antagonism on the appetite center with the ability to stimulate appetite?
A. Hydroxyzine.
B. Loratadine.
C. Diphenhydramine.
D. Cetirizine.
E. Cyproheptadine.
E
Your neighbor said she used an H1 antihistamine that was available over-the-counter (OTC), and it caused her marked drowsiness and dry mouth and she slept quite longer than usual. Which is the most possible drug that she used?
A. Loratadine.
B. Levocetirizine.
C. Diphenhydramine.
D. Fexofenadine.
E. Desloratadine.
C
A patient is going on a deep sea fishing trip and is worried about motion sickness. Which of the following would be the most appropriate?
A. Dimenhydrinate 1 hour prior to departure.
B. Desloratadine 1 hour prior to departure.
C. Doxylamine 1 hour prior to departure.
D. Meclizine at onset of symptoms.
A
A patient has a severe ear infection that is associated
with significant vertigo. Which of the following might be helpful?
A. Azelastine.
B. Brompheniramine.
C. Meclizine.
D. Olopatadine.
C
A 43-year-old heavy machine operator complains of
seasonal allergies. Which medication is most appro-
priate for management of his allergy symptoms?
A. Diphenhydramine
B. Doxylamine
C. Hydroxyzine
D. Fexofenadine
D
Which histamine receptor antagonist is known to
enter the central nervous system readily and cause sedation?
A. Hydroxyzine
B. Cetirizine
C. Desloratadine
D. Loratadine
A
Which drug is an H1-receptor antagonist that also has serotonin receptor antagonism on the appetite center, with the ability to stimulate appetite?
A. Hydroxyzine
B. Loratadine
C. Diphenhydramine
D. Cyproheptadine
D
Which drug for headache is contraindicated in
patients with peripheral vascular disease?
A. Ergotamine
B. Aspirin
C. Acetaminophen
D. Naproxen
A
A 29-year-old woman complains of migraine
LIR_CH39.indd 690 headaches associated with early onset vomiting. Currently, she uses ibuprofen as needed for her migraines, but it is not very effective. Which triptan would be ideal for this patient?
A. Naratriptan
B. Zolmitriptan
C. Frovatriptan
D. Almotriptan
B
A 35-year-old woman is having several severe
migraines per month. The migraines are usually relieved with one or two doses of triptan drugs. Which is most appropriate for prophylaxis to reduce the frequency of her migraines?
A. Dihydroergotamine
B. Ibuprofen
C. Propranolol
D. Sumatriptan
C
A 27-year-old married woman is asking about
treatment options for obesity. She recently stopped taking her birth control medications, as she felt they were contributing to her weight gain. Which medication should be avoided in this patient?
A. Phentermine/topiramate
B. Orlistat
C. Diethylproprion
D. Lorcaserin
A
A fellow healthcare provider is concerned about
prescribing orlistat to adolescent patients. Many of his adolescent patients are stopping the med- ication during the 1st month of treatment. Which side effect is the most likely reason the adoles- cents are stopping orlistat?
A. Valvulopathy
B. Suicidal ideation
C. Drowsiness
D. Flatulence
D
A 38-year-old obese man with depression is con-
sidering a weight loss medication following sev- eral failed attempts with diet and exercise. Which medication could be considered in this individual?
A. Liraglutide
B. Bupropion + naltrexone
C. Orlistat
D. Lorcaserin
C
A 64-year-old man presents with mild-to- moderate
musculoskeletal back pain. He states he has tried
paracetamol without relief. His medical history
includes diabetes, hypertension, hyperlipidemia,
gastric ulcer (resolved), and coronary artery dis-
ease. Which is the most appropriate NSAID regi-
men to treat this patient’s pain?
A. Celecoxib
B. Indomethacin and omeprazole
C. Naproxen and omeprazole
D. Naproxen
C
Which statement is correct regarding the difference
between paracetamol and naproxen?
A. Paracetamol has more anti-in”ammatory effects
compared with naproxen.
B. Paracetamol has more GI side effects but less
NSAIDs like naproxen.
C. Paracetamol has less risk for CV events com-
effects similar to other NSAIDs.
D. Paracetamol has fewer antipyretic effects than
naproxen.
C
Which statement correctly describes the proposed
mechanism of cardioprotection from low-dose aspirin?
A. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in thromboxane A2 levels.
B. Aspirin preferentially inhibits COX-1 to lead to a
relative reduction in thromboxane A2 levels.
C. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in prostacyclin levels.
D. Aspirin preferentially inhibits COX-1 to lead a
relative reduction in prostacyclin levels.
B
Which statement correctly describes the proposed
mechanism of cardioprotection from low-dose aspirin?
A. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in thromboxane A2 levels.
B. Aspirin preferentially inhibits COX-1 to lead to a
relative reduction in thromboxane A2 levels.
C. Aspirin preferentially inhibits COX-2 to lead to a
relative reduction in prostacyclin levels.
D. Aspirin preferentially inhibits COX-1 to lead a
relative reduction in prostacyclin levels.
C
Which statement correctly describes the patho-
physiologic actions of prostaglandins at a target tissue?
A. Promote vasoconstriction in the kidneys
B. Promote sodium and water retention in the
kidneys
C. Decrease secretion of mucus at the lining of the
stomach
D. Decrease secretion of gastric acid in the stomach
C