Intro To CNS Pharmacology 1 Flashcards
What is the importance of studying the actions of drugs on the CNS?
1- used as therapeutic agents.
2- commonly administered for non medical use
Examples of CNS drugs that are used socially?
Tea, coffee, cannabis, nicotine, opiates, amphetamine.
Relieving pain is an example of drug that affect which system..?
CNS
reducing fever an example of drug that affect which system..?
CNS
Suppressing disordered movement an example of drug that affect which system..?
cns
inducing sleep or arousal an example of drug that affect which system..?
cns
reducing appetite an example of drug that affect which system..?
cns
allaying the tendency to vomit an example of drug that affect which system..?
cns
treating anxiety, depression, schizophrenia, Parkinson’s, Alzheimer’s, epilepsy, migraines is an example of drug that affect which system..?
cns
low dopamine and relatively high acetylcholine is an indication of what disease?
parkinson’s
low serotonin and low noradrenaline, is an indication of what disease?
depression
high dopamine, is an indication of what disease?
schizophrenia
what are the 4 ion channels and neurotransmitter receptors in the CNS?
1- voltage- gated channels
2- ligand- gated channels
3- ionotropic receptors.
4- metabotropic receptors.
EPSP is which kind of receptor?
ionotropic
IPSP affect is?
presynaptic inhibition
what are the multiple sites of CNS drug action (hint: there are 7)?
1- conduction.
2- synthesis and storage.
3- release and reuptake.
4- degradation.
5- receptors, pre- and post-synaptic.
6- ion channels.
7- second messengers
fast responses come from which receptors?
Ionotropic (channel-linked).
slow responses come from which receptor?
metabotropic receptors (g-protein-linked)
which kind of receptor is ionotropic receptors?
ligand-gated ion channel
which type of binding directly opens ion channels in ionotropic receptors?
ligand binding
the rate of action in ionotropic receptors is..?
fast action
the latency between NT binding and response in ionotropic receptors is..?
short
the response in ionotropic receptors is..?
brief
ionotropic receptors have ____ (one or multiple?) binding site for neuromodulators?
multiple
ionotropic receptors can enhance or inhibit binding of _____ (exogenous or endogenous?) ligands?
endogenous
which type or receptors are good targets for drugs?
ionotropic receptors.
what is the most common type of receptor?
metabotropic receptors.
which type of receptors are coupled with G protein?
metabotropic receptors.
which receptor has a single subunit with 7 transmembrane spanning domains?
metabotropic receptors.
which type of receptor is highly conserved across the “receptor superfamily”?
metabotropic
where does the ligand bind in metabotropic receptors?
in the cleft on external face.
what activates the various effectors in metabotropic receptors?
G protein
the effectors in metabotropic receptors can be which type of channels?
ion channels
