Intro To CNS Pharmacology 1

Question 1

What is the importance of studying the actions of drugs on the CNS?

Answer 1

1- used as therapeutic agents.
2- commonly administered for non medical use

Question 2

Examples of CNS drugs that are used socially?

Answer 2

Tea, coffee, cannabis, nicotine, opiates, amphetamine.

Question 3

Relieving pain is an example of drug that affect which system..?

Answer 3

CNS

Question 4

reducing fever an example of drug that affect which system..?

Answer 4

CNS

Question 5

Suppressing disordered movement an example of drug that affect which system..?

Answer 5

cns

Question 6

inducing sleep or arousal an example of drug that affect which system..?

Answer 6

cns

Question 7

reducing appetite an example of drug that affect which system..?

Answer 7

cns

Question 8

allaying the tendency to vomit an example of drug that affect which system..?

Answer 8

cns

Question 9

treating anxiety, depression, schizophrenia, Parkinson’s, Alzheimer’s, epilepsy, migraines is an example of drug that affect which system..?

Answer 9

cns

Question 10

low dopamine and relatively high acetylcholine is an indication of what disease?

Answer 10

parkinson’s

Question 11

low serotonin and low noradrenaline, is an indication of what disease?

Answer 11

depression

Question 12

high dopamine, is an indication of what disease?

Answer 12

schizophrenia

Question 13

what are the 4 ion channels and neurotransmitter receptors in the CNS?

Answer 13

1- voltage- gated channels
2- ligand- gated channels
3- ionotropic receptors.
4- metabotropic receptors.

Question 14

EPSP is which kind of receptor?

Answer 14

ionotropic

Question 15

IPSP affect is?

Answer 15

presynaptic inhibition

Question 16

what are the multiple sites of CNS drug action (hint: there are 7)?

Answer 16

1- conduction.
2- synthesis and storage.
3- release and reuptake.
4- degradation.
5- receptors, pre- and post-synaptic.
6- ion channels.
7- second messengers

Question 17

fast responses come from which receptors?

Answer 17

Ionotropic (channel-linked).

Question 18

slow responses come from which receptor?

Answer 18

metabotropic receptors (g-protein-linked)

Question 19

which kind of receptor is ionotropic receptors?

Answer 19

ligand-gated ion channel

Question 20

which type of binding directly opens ion channels in ionotropic receptors?

Answer 20

ligand binding

Question 21

the rate of action in ionotropic receptors is..?

Answer 21

fast action

Question 22

the latency between NT binding and response in ionotropic receptors is..?

Answer 22

short

Question 23

the response in ionotropic receptors is..?

Answer 23

brief

Question 24

ionotropic receptors have ____ (one or multiple?) binding site for neuromodulators?

Answer 24

multiple

Question 25

ionotropic receptors can enhance or inhibit binding of _____ (exogenous or endogenous?) ligands?

Answer 25

endogenous

Question 26

which type or receptors are good targets for drugs?

Answer 26

ionotropic receptors.

Question 27

what is the most common type of receptor?

Answer 27

metabotropic receptors.

Question 28

which type of receptors are coupled with G protein?

Answer 28

metabotropic receptors.

Question 29

which receptor has a single subunit with 7 transmembrane spanning domains?

Answer 29

metabotropic receptors.

Question 30

which type of receptor is highly conserved across the “receptor superfamily”?

Answer 30

metabotropic

Question 31

where does the ligand bind in metabotropic receptors?

Answer 31

in the cleft on external face.

Question 32

what activates the various effectors in metabotropic receptors?

Answer 32

G protein

Question 33

the effectors in metabotropic receptors can be which type of channels?

Answer 33

ion channels