antivirals

Question 1

List antiviral drug groups used for HSV and VZV?

Answer 1

1- oral agents.
2- topical agents.
3- ophthalmic.

Question 2

List oral agents used for HSV and VZV?

Answer 2

• acyclovir.
• valacyclovir.
• famciclovir.

Question 3

List topical agents used for HSV and VSV?

Answer 3

• acyclovir.
• docosanol.
• penciclovir.

Question 4

List ophthalmic agents used for HSV and VSV?

Answer 4

Trifluridine.

Question 5

List acyclovir mechanism of action?

Answer 5

Inhibition of viral synthesis of DNA.

Question 6

Acyclovir competes with what?

Answer 6

Competes with deoxyguanosine triphospahte for viral DNA polymerases.

Question 7

Acyclovir is a _______ analog

Answer 7

Guanosine

Question 8

List formulations of acyclovir?

Answer 8

1- topical.
2- oral.
3- IV.

Question 9

List the spectrum for acyclovir?

Answer 9

Herpes simplex 1 and 2, varicella-zoster virus, possible the Epstein-Barr virus.

Question 10

Which antiviral is the treatment of choice for visceral, disseminated, or central nervous system involvement?

Answer 10

Acyclovir.

Question 11

List acyclovir adverse effects?

Answer 11

1- phlebitis.
2- reversible renal toxicity.
3- neurological symptoms.
4- GI symptoms.
5- headache.
6- TTP/HUS.
7- photosensitivity.
8- anemia.

Question 12

List Anti-CMV agents?

Answer 12

1- ganciclovir.
2- valganciclovir.
3- forscarnet.
4- cidofovir.