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Biochemistry Post Midterm > Lipoproteins I and II > Flashcards

Lipoproteins I and II Flashcards

1
Q

how are lipids transported?

A

transport proteins

majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)

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2
Q

how are lipids transported?

A

transport proteins

majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)

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3
Q

what does albumin transport? what does it not transport?

A

lipids

not cholesterol!

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4
Q

how are lipids bound to albumin?

A

non-covalently

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5
Q

what do lipoproteins transport large amounts of?

A

TAGS and CE in the inner core

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6
Q

what type of plasma membrane does lipoproteins have?

A

monolayer made of phosphatidylcholine (lecithin) and free cholesterol

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7
Q

what has the highest amount of TAGS in lipoproteins?

A

cylomicrons

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8
Q

VLDLs are released by the liver directly into what?

A

blood

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9
Q

what leads to high cholesterol in blood?

A

cylomicrons

VLDL

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10
Q

how are LDLs formed?

A

in bloof from VLDLs

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11
Q

what the highest percentage of cholestryl esters and cholesterol in lipoproteins?

A

LDLs

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12
Q

What are the smallest lipoproteins?

A

HDL

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13
Q

what is HDL -2 rich in?

A

proteins, apolipoproteins

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14
Q

what is LPL?

A

extracellular enzyme mainly bound to capillary walls of heart, skeletal muscle and adipose tissue

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15
Q

how is LPL anchored?

A

heparan sulfate!

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16
Q

What does LPL do?

A

cleave TAGS inside of lipoproteins (chylomicrons) and VLDL (also rich in TAGS)

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17
Q

what does LPL need for activation?

A

Apo C-II

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18
Q

What do chylomicrons obtain in blood from HDL?

A

Apo C-II and apo E

19
Q

Where is Apo B 48 synthesized and what is it needed for?

A

intestinal muscosal cell

release of chylomicrons into lymph

20
Q

how does Apo b 48 and Apo B 100 happen?

A

mRNA editing

21
Q

which LDL is considered to be a risk for CHD?

A

LDL-B

22
Q

what does albumin transport? what does it not transport?

A

lipids

not cholesterol!

23
Q

how are lipids bound to albumin?

A

non-covalently

24
Q

what do lipoproteins transport large amounts of?

A

TAGS and CE in the inner core

25
Q

what type of plasma membrane does lipoproteins have?

A

monolayer made of phosphatidylcholine (lecithin) and free cholesterol

26
Q

what has the highest amount of TAGS in lipoproteins?

A

cylomicrons

27
Q

VLDLs are released by the liver directly into what?

A

blood

28
Q

what leads to high cholesterol in blood?

A

cylomicrons

VLDL

29
Q

how are LDLs formed?

A

in bloof from VLDLs

30
Q

what the highest percentage of cholestryl esters and cholesterol in lipoproteins?

A

LDLs

31
Q

What are the smallest lipoproteins?

A

HDL

32
Q

what is HDL -2 rich in?

A

proteins, apolipoproteins

33
Q

what is LPL?

A

extracellular enzyme mainly bound to capillary walls of heart, skeletal muscle and adipose tissue

34
Q

how is LPL anchored?

A

heparan sulfate!

35
Q

What does LPL do?

A

cleave TAGS inside of lipoproteins (chylomicrons) and VLDL (also rich in TAGS)

36
Q

what does LPL need for activation?

A

Apo C-II

37
Q

What do chylomicrons obtain in blood from HDL?

A

Apo C-II and apo E

38
Q

Where is Apo B 48 synthesized and what is it needed for?

A

intestinal muscosal cell

release of chylomicrons into lymph

39
Q

how does Apo b 48 and Apo B 100 happen?

A

mRNA editing

40
Q

which LDL is considered to be a risk for CHD?

A

LDL-B

41
Q

what is hyperlipidemia Type II a characterized by?

A

high LDL

42
Q

what is hyperlipidemia Type II b characterized by?

A

high LDL

high VLDL

43
Q

what form of app b does intestinal muscosa form?

A

Apo B 48

44
Q

what form a Apo B does liver cells form?

A

Apo B 100

Biochemistry Post Midterm (24 decks)

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