Lipoproteins I and II Flashcards
how are lipids transported?
transport proteins
majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)
how are lipids transported?
transport proteins
majority transported inside lipoproteins (large amounts of TAGS and cholesteryl esters)
what does albumin transport? what does it not transport?
lipids
not cholesterol!
how are lipids bound to albumin?
non-covalently
what do lipoproteins transport large amounts of?
TAGS and CE in the inner core
what type of plasma membrane does lipoproteins have?
monolayer made of phosphatidylcholine (lecithin) and free cholesterol
what has the highest amount of TAGS in lipoproteins?
cylomicrons
VLDLs are released by the liver directly into what?
blood
what leads to high cholesterol in blood?
cylomicrons
VLDL
how are LDLs formed?
in bloof from VLDLs
what the highest percentage of cholestryl esters and cholesterol in lipoproteins?
LDLs
What are the smallest lipoproteins?
HDL
what is HDL -2 rich in?
proteins, apolipoproteins
what is LPL?
extracellular enzyme mainly bound to capillary walls of heart, skeletal muscle and adipose tissue
how is LPL anchored?
heparan sulfate!
What does LPL do?
cleave TAGS inside of lipoproteins (chylomicrons) and VLDL (also rich in TAGS)
what does LPL need for activation?
Apo C-II
What do chylomicrons obtain in blood from HDL?
Apo C-II and apo E
Where is Apo B 48 synthesized and what is it needed for?
intestinal muscosal cell
release of chylomicrons into lymph
how does Apo b 48 and Apo B 100 happen?
mRNA editing
which LDL is considered to be a risk for CHD?
LDL-B
what does albumin transport? what does it not transport?
lipids
not cholesterol!
how are lipids bound to albumin?
non-covalently
what do lipoproteins transport large amounts of?
TAGS and CE in the inner core
