Lipoprotein Review Slides

Question 1

Where are chylomicrons formed?

Answer 1

The small intestine

Question 2

What is the main lipid in a chylomicron?

Answer 2

TAG

Question 3

What is the main apoprotein component of a chylomicron?

Answer 3

B-48

Question 4

What is the function of a chylomicron?

Answer 4

Transports dietary TAG to adipose and other tissues

Question 5

What is the main lipid of a chylomicron remnant

Answer 5

TAG

Question 6

What is the main apoprotein in chylomicron remnants?

Answer 6

B-48

Question 7

What is the function of a chylomicron remnant?

Answer 7

Delivery of dietary TAG to the liver

It exchanges TAG for CE from HDL and delivers CE to the liver

Question 8

Where is VLDL formed?

Answer 8

In the liver

Question 9

What is the main lipid in VLDL?

Answer 9

TAG

Question 10

What is the main apoprotein in VLDL?

Answer 10

B-100

Question 11

What is the function of VLDL?

Answer 11

Transports endogenously synthesized TAG to adipose tissues (and skeletal and heart tissue)

Exchanges TAG for CE from HDL.

Question 12

WHere is IDL formed?

Answer 12

IDL is a remnant of VLDL. It is formed in the processing of VLDL

Question 13

What is the main lipid in IDL?

Answer 13

TAG and cholesterol

Question 14

What is the main apoprotein in IDL?

Answer 14

B-100, E

Question 15

What is the function of IDL?

Answer 15

Delivers remaining TAG and cholesterol to the liver

Question 16

Where are LDLs formed?

Answer 16

Formed via processing of IDL in the circulation

Question 17

What is the main lipid in LDL?

Answer 17

Cholesterol

Question 18

What is the main apoprotein in LDL?

Answer 18

B-100

Question 19

What is the function of LDL?

Answer 19

Delivers cholesterol to the liver and other cells

Question 20

Where is HDL formed?

Answer 20

The liver, although some is formed in the intestine

Question 21

What is the main lipid in HDL?

Answer 21

Cholesterol

Question 22

What is the main apoprotein of HDL?

Answer 22

A

Question 23

What is the function of HDL?

Answer 23

Transport of CE to the liver

HDL accepts cholesterol from peripheral cells, esterifies it, and transports it to the liver. It exchanges CE for TAG in VLDL, IDL and chylomicron remnants.

It is atheroprotective via enzymes such as paroxonase that inhibit LDL oxidation.

It serves as a reservoir for circulating apoproteins (ACE) which are transported to other lipoprotein particles.

Question 24

What is the major difference between chylomicrons and VLDL, IDL and LDL?

Answer 24

Chylomicrons transport dietary (exogenous) lipids

VLDL, IDL and LDL transport synthesized (endogenous) lipids

Question 25

Apo-CII activates which enzyme?

Answer 25

lipoprotein lipase

Question 26

Apo-AI activates which enzyme?

Answer 26

lecithin:cholesterol acetyltransferase (LCAT)

Question 27

Apo E is the ligand for what receptor?

Answer 27

Remnant receptor

Question 28

Apo B-100 is the ligand for what receptor?

Answer 28

LDL receptor

Question 29

Apo A-1 is the ligand for what receptor?

Answer 29

HDL receptor

Question 30

B-48 is the structural protein for which apolipoproteins?

Answer 30

chylomicrons

Question 31

B-100 is the structural protein for which apolipoproteins?

Answer 31

VLDL and LDL

Question 32

A-1 is the structural protein for which apolipoprotein?

Answer 32

HDL

Question 33

WHat is a normal total cholesterol level?

Question 34

What is the optimal total cholesterol: HDL ratio?

Answer 34

3.3:1