Gluconeogenesis Flashcards
1
Q
Glucose homeostasis requires two pathways that take place in the liver. What are they?
A
Gluconeogenesis and glycogen degradation
2
Q
What is gluconeogenesis?
A
The net synthesis of glucose from non-carbohydrate substrates including:
Pyruvate
Lactate
Glycerol
Glucogenic amino acids
3
Q
What is the common intermediate between glycogenolysis and gluconeogenesis?
A
Glucose-6-phosphate
4
Q
What does it cost to convert 1 lactate to 1 molecule of glucose?
A
6 ATP
5
Q
When is gluconeogenesis activated?
A
After dietary glucose has been oxidized and glycogen has been used up
6
Q
What is required for the conversion of pyruvate to PEP?
A
2 step process: Pyruvate –> oxaloacetate —> PEP
Bicarbonate and biotin (cofactor) are also both required, along with ATP
