Lipogenesis

Question 1

Location

Answer 1

Cytoplasm of all cells when needed…except muscle

Question 2

Lipogenesis catalyzed by

Answer 2

FAS complex > 2 F.A.

Question 3

FAS complex associated with

Answer 3

ACP

Question 4

O-Carbon and the one next to it come from _ while the rest come from _

Answer 4

Acetyl CoA, malonate

Question 5

How does acetyl CoA enter cytoplasm for lipogenesis?

Answer 5

Oxac + aCoA > citrate.
Citrate carrier takes it to cytoplasm
Citrate lyase breaks it down to OXAC and aCoA

Question 6

How do you produce CO2 and NADPH needed for lipogenesis

Answer 6

OXAC > malate > pyruvate by NADP-linked MALIC

Question 7

RDS?

Answer 7

Acetyl CoA Carboxylase(ACC)
- Acetyl CoA > malonyl CoA
- ATP + biotin
- Irreversible

Question 8

2 types of elongases add 2C to produce a longer F.A.

Answer 8

• Mitochondrial elongase:
  C donor is acetyl CoA
• ER elongase:
  C donor is malonyl CoA

Question 9

T/F: Humans can desaturate between C9 and O-C?

Answer 9

False. Plants can. Humans only between C9 and carboxyl

Question 10

Malonly CoA decarboxylase:
Active by _
Inactive by _

Answer 10

Phosphorylation > less malonate > B-ox
Dephosphorylation > more malonate > Lipogenesis

Question 11

T/F: Cells are continuously synthesizing F.A

Answer 11

False. Only when needed

Question 12

High cbhy/protein diet…FAS _
Fasting/Lipid diet…FAS _

Answer 12

more active
less active