Lipogenesis Flashcards
Location
Cytoplasm of all cells when needed…except muscle
Lipogenesis catalyzed by
FAS complex > 2 F.A.
FAS complex associated with
ACP
O-Carbon and the one next to it come from _ while the rest come from _
Acetyl CoA, malonate
How does acetyl CoA enter cytoplasm for lipogenesis?
Oxac + aCoA > citrate.
Citrate carrier takes it to cytoplasm
Citrate lyase breaks it down to OXAC and aCoA
How do you produce CO2 and NADPH needed for lipogenesis
OXAC > malate > pyruvate by NADP-linked MALIC
RDS?
Acetyl CoA Carboxylase(ACC)
- Acetyl CoA > malonyl CoA
- ATP + biotin
- Irreversible
2 types of elongases add 2C to produce a longer F.A.
- Mitochondrial elongase:
C donor is acetyl CoA - ER elongase:
C donor is malonyl CoA
T/F: Humans can desaturate between C9 and O-C?
False. Plants can. Humans only between C9 and carboxyl
Malonly CoA decarboxylase:
Active by _
Inactive by _
Phosphorylation > less malonate > B-ox
Dephosphorylation > more malonate > Lipogenesis
T/F: Cells are continuously synthesizing F.A
False. Only when needed
High cbhy/protein diet…FAS _
Fasting/Lipid diet…FAS _
more active
less active