Lipogenesis Flashcards

1
Q

Location

A

Cytoplasm of all cells when needed…except muscle

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2
Q

Lipogenesis catalyzed by

A

FAS complex > 2 F.A.

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3
Q

FAS complex associated with

A

ACP

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4
Q

O-Carbon and the one next to it come from _ while the rest come from _

A

Acetyl CoA, malonate

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5
Q

How does acetyl CoA enter cytoplasm for lipogenesis?

A

Oxac + aCoA > citrate.
Citrate carrier takes it to cytoplasm
Citrate lyase breaks it down to OXAC and aCoA

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6
Q

How do you produce CO2 and NADPH needed for lipogenesis

A

OXAC > malate > pyruvate by NADP-linked MALIC

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7
Q

RDS?

A

Acetyl CoA Carboxylase(ACC)
- Acetyl CoA > malonyl CoA
- ATP + biotin
- Irreversible

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8
Q

2 types of elongases add 2C to produce a longer F.A.

A
  • Mitochondrial elongase:
    C donor is acetyl CoA
  • ER elongase:
    C donor is malonyl CoA
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9
Q

T/F: Humans can desaturate between C9 and O-C?

A

False. Plants can. Humans only between C9 and carboxyl

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10
Q

Malonly CoA decarboxylase:
Active by _
Inactive by _

A

Phosphorylation > less malonate > B-ox
Dephosphorylation > more malonate > Lipogenesis

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11
Q

T/F: Cells are continuously synthesizing F.A

A

False. Only when needed

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12
Q

High cbhy/protein diet…FAS _
Fasting/Lipid diet…FAS _

A

more active
less active

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