HMP

Question 1

Location

Answer 1

Cytosol of liver, mammary glands, adrenal cortex, adipose, RBC…not skeletal muscle

Question 2

RDS?

Answer 2

G6P DH (NADP requiring)
G6P > 6-phosphogluconolacton

Question 3

Transketolase needs _ and _

Answer 3

TPP and Mg2+

Question 4

GSSG > 2 GSH via what enzyme

Answer 4

GSH reductase(NADPH requiring)

Question 5

T/F: NADPH protects cells form oxidative damage

Answer 5

True

Question 6

GSH:GSSG should be at?

Answer 6

500

Question 7

Basis of G6P DH deficiency
What triggers?

Answer 7

• NADPH not generated > GSH not regenerated > oxidative stress and hemolysis
• Fava beans, drugs, antibiotics. aspirin, primaquine

Question 8

Warburg effect

Answer 8

Glucose > lactate in aerobic conditions

Question 9

Lactose intolerance caused by

Answer 9

Deficiency in lactase(lac > gal)

Question 10

Deficiency of uridyl transferase?

Answer 10

Gal1P > galactosemia > galactitol via aldol reductase….cataract

Question 11

Fructose metabolism occurs in

Answer 11

Liver(main) and muscle

Question 12

T/F: Fructokinase converts F > F1P in muscle

Answer 12

False. It is liver specific. This rxn occurs in liver

Question 13

Deficiency in aldolase B?

Answer 13

fructose intolerance