A.A. + urea cycle Flashcards
1
Q
Ketogenic:
Glucogenic:
Both:
A
- Lys, Leu
- Ala, ser, glu, asp
- Trp, Ile
2
Q
Improper intake of E.A.A.
A
Protein energy malnutrition
3
Q
- Phase 1 of protein digestion occurs in _
- Enzymes involved
- Pepsinogen > pepsin via ?
A
- Stomach
- Gastrin, pepsin
- HCL
4
Q
- Phase 2 of protein digestion occurs in _
- Enzymes involved
- Trypsinogen > trypsin via?
A
- Intestine
- Pancreozymin/cholecystokinin, secretin, trypsin
- Enterokinase
5
Q
Deficiency of pancreatic secretion
A
Steatorrhea(Fatty poop)
6
Q
A.A. absorption occurs in _
A
Intestine
7
Q
A.A transport across serosal membranes is
A
Bidirectional
8
Q
GSH should be high is which organs?
A.A. absorption via?
Transports A.A as _
A
- RBC, intestine, kidney
- Y-glutamyl cycle
- Dipeptides
9
Q
GSH synthase deficiency
A
- Oxoprolinuria(hemolytic anemia)
- y-glu-cys accumulates
- Oxoproline excreted in urine
- Less GSH > oxidative stress
10
Q
Proteases help recognize what protein to degrade. 2 types and their subtypes.
A
- Lysosomal: Cathepsins
- Cytosolic: Calpains, metalloproteinases
11
Q
PEST sequences
A
- Proteins with short half life
- Pro, glu, ser, thr
12
Q
D-oxidases
A
- Irreversible
- In peroxisomes of liver, kidney
- Uses FAD, FMN
13
Q
Glutamate DH
A
- In mitochondria
- Reversible
- Glu > @KG + NH3
- Forward by NAD, backwards by NADPH
14
Q
T/F: If NH3 is high, glutamate DH favors glutamate formation
A
True(backwards rxn)
15
Q
Non-ox deamination:
Which A.A.?
A
- Enamine > imino > @ketoacid + NH3
- Ser, thr, cys
