lipids

Question 1

lipid function

Answer 1

Energy storage : TAG and adipose tissue
Membrane components : PL, SL, Chol
Surface Active Properties: PL, Bile Acids
Specific Biological Properties : PG, TXB, LKT, Steroid hormones

Question 2

Chemical properties of FA: FA have little attracction for water because ?

Answer 2

long acyl chains w/ terminal -COOH

Question 3

Chemical Properties of FA ?

Answer 3

: Little Attraction for Water

2. Significant attraction for fatty alkyl chains
3. Chemically Inert (generally)

Question 4

types of endogenously synthesized lipids in lipid pool?

Answer 4

TAG, FA, PL,SL, Lipoproteins

Question 5

energy production from the lipidpool is made so by ?

Answer 5

beta oxidation

Question 6

complex lipid synthesis in the lipid cool consist of ?

Answer 6

Prostoglandins, LKT, Bile Salts, Steroid Hormones

Question 7

in palmitate synthesis : All carbons derived from?

Answer 7

acetyl coa

Question 8

describes the acetyl co’s in palmitate synthesis

Answer 8

1st has a methyl end

all others are converted to malonyl coa

Question 9

2 enzymes involved in palmitate synthesis

Answer 9

a. Acetyl CoA CO2lase

b. FA synthase

Question 10

hi CHO/lo FAT will cause

Answer 10

increased enzyme levels)… need to make fat

Question 11

hi FAT/fasting will cause

Answer 11

(decreased enzyme levels) … need to degrade fat

Question 12

describe de novo PL Synthesis

Answer 12

1. synthesize DAG
2. Synthesize activated polar head
3. reaction of DAG with Polar head will give PL

Question 13

PL Synthesis from pre existing Phospholipids ?

Answer 13

Base modification reaction
P-serine removes CO2 to give P-ethanolamine
P-ethanolamine adding 3SAM to give P-choline

Base exchange
P-serine adding serine to give P-serine+ethanolamine

Question 14

Plasmologens are present in ?

Answer 14

myelin and heart tissue

Question 15

what is plasmologens role during hemostasis

Answer 15

mediating platelet aggregation

Question 16

prostaglandins ?

Answer 16

are made at sites of tissue damage or infection, where they cause inflammation, pain and fever as part of the healing process

Question 17

prostaglandins are synthesized from ?

Answer 17

from polyunsaturated FA…..20 carbons

Question 18

3 major classes of prostaglandins?

3 major series ?

Answer 18

AEF

1.2.3.

Question 19

Class A PG=?
Class E PG=?
Class F PG=?

Answer 19

1keto group and 1 double bond
1 keto group and 1 hydroxyl
2 hydroxyls

Question 20

types of series ?

1,2,and 3 are produced from ?

Answer 20

2=arachidonic acid
1=dihomo-gamma linoleic acid
3= eicosapentaenoic acid

Question 21

inhibitor of arachidonic acid

Answer 21

anti inflammatory steroids

Question 22

inhibitor of Prostaglandins ?

Answer 22

NSAIDs- Asprin and Indomethacin Phenylbutazone

Question 23

lox enzymes in leukotriene synthesis

Answer 23

5-lox, 12-los, 15-lox

Question 24

leukotriene synthesis ?

Answer 24

in notes

Question 25

cox are inhibited by ?

Answer 25

NSAIDs

Question 26

cox 1 ?

Answer 26

constituitive: housekeeping of Gastric mucosa,renal blood flow and platelet function

Question 27

cox 2

Answer 27

induced in response to pain fever or inflammation

Question 28

cox 2 is inhibited by

Answer 28

glucocoritcoids

Question 29

specific drugs that inhibit cox 2 ?

Answer 29

COX-2 inhibitors ….
celecoxib (Celebrex)
rofecoxib (Vioxx)
meloxicam (Mobic)