Lipids 3 Flashcards
Where do we get FA’s?
- Diet
- Synthesis
Where does FA synthesis occur in the body?
- Liver
- Lactating mammary
- Adipose tissue
Where does synthesis occur in the cell?
Cytosol
What are FA’s synthesised from?
Acetyl CoA
Where is the acetyl CoA from in FA synthesis?
Mitochondria
When does the citrate cycle occur? (when what is in high concentration)?
Citrate
What 2 enzymes are required for FA synthesis?
- Acetyl CoA carboxylase
- FA synthase
What are the 2 required molecules for synthesis?
- Acetyl CoA
- NADPH
What is the product of FA synthesis?
Palmitic Acid
What is acetyl CoA initially converted to?
Malonyl CoA
What other action does Malonyl CoA have to stop synthesis and degradation occurring simultaneously?
Inhibits carnitine palmitoyl transferase
What activates acetyl CoA carboxylase?
- Citrate
- Insulin
What deactivates acetyl CoA carboxylase?
- Palmitoyl CoA
- Glucagon
- Epinephrine
What does malonyl CoA combine with in the elongation reaction
Acetyl ACP
What happens after elongation?
The reverse of FA degradation
