lipid lowering agents Flashcards
first type of drug used for hyperlipidemia?
statin
atorvastatin action
-blocks cholesterol production
-reabsorbs cholesterol buildup in plaques
-decreases LDL & increases HDL
atorvastatin indications
-hyperlipidemia, CAD, post-CVA
atorvastatin adverse reaction
-myopathy
-hepatoxivity
atorvastatin drug interactions
grapefruit juice
atorvastatin assessment
monitor:
-creatinine
-kinase levels
-renal function (myopathy)
-LFTs at 12 weeks then q6 months (hepatotoxicity)
atorvastatin teaching points
-report muscle weakness or tenderness
-avoid grape fruit juice
what is the second line of medication for hyperlipidemia?
ezetimibe
ezetimibe adverse effects
-myopathy
-hepatoxicity - use with statins increased risk
ezetimibe drug to drug interactions
-statins
-cholestyramine
-gemfibrozil
ezetimibe assessment
monitor:
-creatinine kinase levels
-renal function (myopathy)
-LFTs
ezetimibe teaching points
report muscle weakness or tenderness
colesevelam action
decreases LDL
colesevelam drug to drug interactions
-many b/c of interference with absorption
-take 1 hour before or 4 hours after other meds
colesevelam assessment
monitor bowel movements
colesevelam teaching points
-increase fiber and fluids
-take mild laxative if needed for constipation
gemfibrozil action
-decreases triglyceride
-increase HDL
gemfibrozil adverse effects
-mild GI distress
-gallstones
-myopathy
-hepatotoxicity
gemfibrozil drug to drug interactions
-statins
-warfarin
gemfibrozil teaching
-monitor for abdominal pain
-muscle aches
-jaundice
