Limbic System Flashcards
this structure involved in earliest loss of alzheimer’s disease…memory loss
entorhinal cortex
blood supply to hypothalamus and anterior thalamus
circle of willis
efferent pathway of HF
CA1 - subiculum - alveus/fimbria/fornix - precommissural (to septal nuclei, frontal cortex, hypothalamus, nucleus accumbens) or postcommisural (to medial mammillary nucleus of hypothalamus)
cortical structures that form the limbic lobe (grand lobe limbique)
subcallosal area, cingulate gyrus and isthmus of cingulate, parahippocampal gyrus (and hippocampal formation),uncus
visceral and motor responses of limbic system
homeostatic functions, olfaction, memory, emotion and drives (also reproduction, defense)
input to the septal area
hippocampus and amygdala
output of septal nuclei to the habenular nuclei via this
medullary stria thalamus
this output of septal area enables limbic system to influence visceral responses to emotion events
medullary stria
blood supply to hippocampal formation, amygdala, stria terminalis
anterior choroidal
3 primary regions of hippocampal formation
dentate gyrus, hippocampus proper, subiculum
plays key role in temporal lobe memory system, declarative memory
hippocampus
where are neurofibrillary tangles found in Alzhemier disease?
subiculum and entorhinal cortex
major efferent connections from hippocampus travel via this
subiculum
refers to major structures of limbic system
medial temporal lobe
CA3 projects to CA1 pyramidal cells via these (connect CA3 to CA1); what does this allow?
Schaffer collaterals; long-term potentiation
these help hippocampus ‘map’ the environment…take visual/olfactory/motor sensations to build memory (creates context)
place cells
afferent hippocampal circuitry (*perforant pathway*)
entorhinal - granule of Dentate gyrus - dendrites pyramidal CA3 - fornix or CA1 pyramidal cells - fornix
where is working memory located?
dorsolateral prefrontal cortex
synaptic layer of hippocampal formation
molecular
primary neuron in dentate gyrus
granule cell
CA1 pyramidal cells leave hippocampus via this
fornix
majority of symptoms seen in Kluver Bucy syndrome are due to damage/removal of this
amygdala
subcortical nuclei included in limbic system
septal, nucleus accumbens, hypothalamic, thalamic, habenular
NT for projections from septal nuclei/nucleus accumbens to HF
Ach