limbic Flashcards
excitation of cortical activity
BFA in pons/midbrain
inhibition of cortical activity
medial/ventrla medulla
reticular formation includes BFA; located where and mediates what?
in upper pons (midbrian)
mediates arousal and alertness
excitatory NT from BFA
acetylcholine
excitatroy NT from substantia nigra
dopamine
excitatory NT from locus ceruleus
NE
inhibitory NT from raphe nuclei (rostral and ventral divisions)
serotonin
Gigantocellular neurons in BFA ascend to ____ and descends to _____.
ascends to thalamic nuclei for arousal
descends to spinal cord for tone of antigravity muscles
Parvocellular neuronston intralaminar nuclei (thalamus) does what?
modulates pain pathways
What becomes active during REM sleep phase?
NE
Locus ceruleus (midbrain) diffuse excitation tot cortex for wakefulness
NE
substantia nigra neurons to putamen/caudate control of movement/thoguht
dopamine
receptors for excitatory dopamine
D1 receptors (inncrease cAMP)
receptors for inhibitory dopamine
D2 receptors
decrease in cAMP– rare
ventral tegmental area (VTA) neurons to limbic structures influence..
mood
schizophrenia in the VTA
lack of focused thought
cell bodies in raphe nuclei
serotonin
dorsal raphe projects to what 4 places
thalamus, cortex, cerebellum, BFA
serotonin in dorsal raphe inihibts what
inhibits cortical activity
inihibition of BFA induces sleep
caudal raphe project where?
to spinal cord and suppress pain pathways
5 functions of the hypothalaus under vegetative control
- ANS
- endocrine system regulation
- core body temp
- feeding
- sleep
conscious hypothalamus
- rage vs fight or flight
2. reward and punishment
define limbic system
neuronal circuits involved in memory that influence behavior and motivation
what does HOME stnad for
homeostasis, olfaciton, memory, emotion
lateral area of the mid-hypothalamus
inhibtiory to adjacent hypothalamic nuclei for reciprocal control of feeding, thirst, rage
perventricular area of the mid-hypothalamus
septum area and nucleus accumbens (reward center circuitry)
3 regions of the hypothalamus
anterior (2)
tuberal (6 nuclei)
posterior (2)
decrease feeding hormones from the hypothalamus
alpha-MSH, leptin, insulin, CCK, peptide YY (PYY)
increase feeding hormones from the hypothalamus
neuropeptide Y, orexins A & B, ghrelin
What 2 nuclei regulate feeding and energy expenditure?
arcuate and paraventricular
role of anterior nucleus in core temperature
heat dissipation
- sweating
- panting
- behavioral adaption
role of posteriror nucleus in core temperature
heat conservation
- shivering
- increase TSH and increased metabolism
- behavorial adaption
Wakefulness innducers orexin A, B located where?
lateral hypothalamus
wakefulness inducer histamine is located where?
posterior hypothalamus
Where are the reward centers?
lateral and VM nucleus of hypothalamus
others include amygdala and septum
Where is the punishment center located?
periaqueductal gray (PAG) in midbrain (most potent)