Limb Developement (Movement / Embryology / Anatomy) Flashcards

1
Q

When does limb developement occur?

A

5-8weeks

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2
Q

In what weeks are the limb buds visible as outpouchings from the ventrolateral body wall?

A

end of week 4

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3
Q

The mesoderm core of the limb bud differentiates into mesenchyme. What does this form in the limb/

A

Bones and connective tissue

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4
Q

What does the paraxial mesoderm form?

A

Paraxial mesoderm forms somites. The somites differentiate into structures - including skeletal muscle of limb.

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5
Q

The somites divide into the sclerotome and dermomyotome what do these give rise to?

A

Sclerotome = vertebral bodies

Dermomytome = skin and skeletal muscle

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6
Q

The epimere makes up the back muscles. What are they innervated by?

A

Dorsal rami of the spinal nerves

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7
Q

The hypomere makes up the muscles of the thoracic / abdo walls also muscles of the limbs. what are they innervated by?

A

ventral rami of the spinal nerves

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8
Q

Where does the limb musculature derive from?

A

Myotomt divides into epimere and hypomere. Limb muscles are from hypomere.

*Paraxial mesoderm&raquo_space;>Somites»>dermomyotome»>myotome»>Hypomere

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9
Q

What is the upper limb inneravatd by?

A

brachial plexus (C5 - T1)

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10
Q

What is the lower limb innervated by?

A

lumbosacral plexus (L4-S3)

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11
Q

During limb rotation in which direction do the limbs rotate?

A

Upper limb = 90’ laterally so the flexors lie anteriorly

Lower Limb = 90’ medially so flexors lie posteriorly

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12
Q

When does limb rotation occur?

A

between weeks 6-8

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13
Q

What dermatome supplies the thumb?

A

C6

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14
Q

What dermatome supplies the 3 digit?

A

C7

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15
Q

What dermatome supplies the 5th digit?

A

C8

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16
Q

What does the lateral plate mesoderm, forming the mesenchymal core of the limb bud secrete.???
(It enduces thickening of the overlying ectoderm along the tip of the limb bud)

A

Fibroblast growth factor (Fgf 10)

17
Q

Fibroblast growth factor (Fgf 10) induces thickening of the overlying ectoderm along the tip of the limb bud. What is this thickening called?

A

Apical ectodermal ridge (AER)

18
Q

The apical ectodermal ridge expresses fibroblastic growth factors that cause rapid proliferation of the mesenchymal cells underlying the AER, the progress zone. What are these growth factors?

A

Fgf 4 and 8

19
Q

What growth factors causes proliferation of the progress zone. (are secreted by the apical ectodermal ridge)

A

Fgf 4 and Fgf 8

20
Q

Control of dorsoventral patterning:

the dorsal ectoderm expresses Wnt7, what does the ventral ectoderm express?

A

Ventral ectoderm expresses engrailed-1 , this inhibits Wnt7

21
Q

Sonic hedghog (Shh) controls craniocaudal patterning. A high conc of Shh induced formation of the little finger. Low conc induces formation of the thumb. Where is Shh expressed?

A

Shh is expressed in the caudal part of the limb bud called the zone of polarising activity (ZPA)

22
Q

What is Amelia?

A

complete abscence of a limb

23
Q

What is meromelia

A

partiall abscence of a limb

24
Q

What is phocomelia?

A
  • digits develop prematurely
  • limbs get shorter

(can be caused by thalidomide)

25
Q

What limb malformation is caused by thalidomide?

A

Phocomelia - premature development of limbs. (limbs are shorter)

26
Q

What is syndactyly?

A

fused digits caused by failure of apoptosis

27
Q

What is polydactyly?

A

extra digits

caused by inappropriate Shh expression

28
Q

What is ectrodactyly?

A

Split hand / foot

caused by the apicle ectodermal ridge to form properly