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Infectology > Licosamidas > Flashcards

Licosamidas Flashcards

1
Q

¿Cómo trabajan las LICOSAMIDAS (CLINDA)?

A

inhiben la síntesis de proteínas uniéndose a la unidad ribosomal 50S.

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2
Q

¿Las licosamidas son bacteriostáticos o bactericidas?

A

Bacteriostáticos

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3
Q

Vía de administración

A

IM (PNEUMOCYSTIS JIROVECII)
VO
EV

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4
Q

Vía de excreción

A

Hepática

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5
Q

Cobertura de las licosamidas (CLINDAMICINA)?

A

GRAM + : Estreptococo, MRSA
Anaerobios (B. fragilis 75%) (Peptoestreptococo)
Otros: Toxoplasma, BABESIA (2da línea)
PNEUMOCYSTIS JIROVECII

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6
Q

Efectos adversos

A

Diarrea asociada a ATB

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7
Q

Categoría en el embarazo

A

B

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8
Q

¿Cruzan la BHE?

A

ÑO

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9
Q

¿Tiene circulación enterohepática?

A

Sí, está es una de las causas de su larga duración

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10
Q

¿Tiene actividad contra C. difficile?

A

No, por eso causan diarrea.

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11
Q

¿Cubren B. fragilis?

A

Sí, pero un 25% son resistentes por eso no lo utilizo en primera línea en perforación intestinal.

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12
Q

Indicaciones

A
  • Fascitis necrotizante
  • NAC por anaerobios
  • IPTB
  • Osteomielitis
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13
Q

¿La Clinda es de elección en perforación intestinal?

A

No, pq un 25% de Bacterioides fragilis son resistentes a ella

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14
Q

Tx de px alérgico a sulfas

A

Clinda

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15
Q

Tx de abceso pulmonar

A

Clinda

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Infectology (13 decks)

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