Leukocyte Antigen and Relationship Testing ( Chapter 21 )

Question 1

Is a specialized branch or division in immunology for human histocompatibility testing

Answer 1

Human Leukocyte Antigen Testing

Question 2

The first known HLA molecule

Answer 2

HLA-A2

Question 3

Is a series of closely linked genes that determine major histocompatibility factors - that is surface antiges or receptors

Answer 3

Human Leukocyte Antigen Region/Major histocompatibility complex

Question 4

What part of chromosome 6 can u find Class 1 HLA molecule

Answer 4

telomere

Question 5

What part of chromosome 6 can u find Class 2 HLA molecule

Answer 5

Centromere

Question 6

Where can u find HLA antigen

Answer 6

short arm of chromosome 6

Question 7

what are the classic DR specificities

Answer 7

DRB1 , DRB3 (DR52 molecule) , DRB4 (DR53 molecule) DRB5 (DR51 molecule )

Question 8

Class 3 regions structurally and functionally diverse molecules

Answer 8

C2 , C4 , Bf ( the complement factors ) , 21 - hydroxylase and tumor necrosis factor , GLO

Question 9

Is present to distinguish them as significant serologic epitopes found on multiple HLA-A and HLA-B alleles rather than independent HLA specificities.

Answer 9

Bw4 amd Bw6

Question 10

In HLA Gene a capital Letter indicates ______

Answer 10

specific locus

Question 11

In HLA gene the second letter indicates

Answer 11

Subregion

Question 12

In HLA gene the two digital numeral defines

Answer 12

Serologic Group Reactivity

Question 13

In HLA gene the allele family separated by a colon

Answer 13

Specific Alleles

Question 14

An event that infrequently complicates HLA-typing interpretation and haplotype determination is _______

Answer 14

Crossing Over/Recombination

Question 15

It is when HLA genes occur more frequently in the same haplotype than would be expected by chance alone

Answer 15

Linkage Disequilibrium

Question 16

Is used to prevent evaporation in antisera

Answer 16

Mineral Oil