Lesson 9 Flashcards

1
Q

refers to the use of drugs or chemicals to treat or prevent diseases caused by infectious organisms

A

Chemotherapy

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2
Q

In popular usage, we associate the term chemotherapy with drug treatment of

A

cancer

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3
Q

Drugs used for chemotherapy are generally called?

A

Chemotherapeutic agents, anti-infective agents

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4
Q

It is the propertyof substances of being more harmful to certain living organisms but not to others

A

Selective toxicity

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5
Q

a natural or synthetic drug that acts against one or more types of microorganisms

A

anti-microbial

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6
Q

refers strictly to a substance produced by various species of microorganisms inhibiting the growth of another microorganisms

A

antibiotic

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7
Q

include not only those that are naturally produced but also those that are partly or fully synthesized in pharmaceutical laboratories

A

antibiotics

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8
Q

The drug is capable of killing bacterial organisms at clinically achievable concentrations

A

bacteriocidal

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9
Q

Inhibition of growth after the antibiotic level falls off below the MIC

A

post-antibiotic effect

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10
Q

The lowest concentration or dilution of drugs that sterilizes the medium or results in a 99.9% decline in bacterial count

A

minimum bacteriocidal concentration

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11
Q

lowest dilution of drug that prevents visible growth in broth or agar after 18 – 24 hours of incubation

A

minimum inhibitory concentration

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12
Q

drug, at clinically achievable concentrations, inhibits bacterial growth but does not kill the organisms

A

bacteriostatic

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13
Q

An antibacterial agent which cause dissolution of bacterial cells

A

bacteriolytic

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14
Q

Inhibit bacterial growth and replication

A

bacteriostatic

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15
Q

Bacteriocidal that require active multiplication of bacteria to be effective

A

penicillins, cephalosphorins

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16
Q

more prone to causing superinfections because they may kill off normal bacterial flora which normally inhibits pathogens

A

bacteriocidal

17
Q

These drugs are against gram + cocci and bacilli

A
  1. natural penicillins
  2. semi-synthetic penicillins
  3. macrolides
  4. lincosamides
  5. vancomycin and bacitracin
18
Q

drugs against gran negative bacilli

A
  1. aminoglycosides
  2. polymyxins
19
Q

How does the DRUG ACTS ON PATHOGEN

A

Eradication, inhibition of growth, selective pressure

20
Q

How does the PATHOGEN ACTS ON DRUG

A

Inactivation of the drug, drug resistance

21
Q

How does the DRUGS ACT ON THE HOST

A

Toxicity, allergy, biological alteration, immunosuppression

22
Q

How does HOST ACTS ON DRUG

A

Excretion and biotransformation

23
Q

How does PATHOGEN ACTS ON HOST

A

Causes the diseases

24
Q

How does the HOST ACTS ON PATHOGEN

A

Immune mechanisms eliminates the pathogen and resolves the diseases

25
Q

Broad – spectrum drugs

A
  1. Cephalosporins
  2. trimethoprim
  3. tetracyclines
26
Q

Drugs that are inhibitors of cell wall synthesis

A

Penicillin, Cephalosporins, Bacitracin, and Vancomycin

27
Q

They have a greater tendency to induce superinfections

A

Inhibitors of cell wall synthesis

28
Q

Disruptors of cell membrane drugs

A

Polymyxins

29
Q

Inhibitors of protein synthesis drugs

A

Aminoglycosides, Tetracyclines, Macrolides, Lincosamides, Chloramphenicol, Tiamulin, and Virginiamycin

30
Q

Inhibitors of Folate Cofactor Synthesis drugs

A

Sulfonamides, Trimethoprim, Flouroquinones