Lesson 3.9 - Gonorrhea

Question 1

Characteristics of Neisseria spp.

[Motility, Gram, Aerotolerance, etc.]

Answer 1

• Nonmotile, Gram -, Aerobic or microaerophilic
  
  • Several other spp. are benign commensals of mucous membranes

Question 2

Neisseria gonorrhoeae Characteristics

[Shape, transmission, Mortality rate]

Answer 2

• Gonococcus
• Transmitted by sexual contact
  
  • Attach to lumen of urethra, vagina, anus, conjunctiva, and pharynx
• Low mortality rate
  
  • 1k worldwide

Question 3

Symptoms of Gonorrhea [Male & Female]

Answer 3

• Male
  
  • Purulent [pus] urethral discharge
  • Painful urination
• Female
  
  • 50-80% asymptomatic
  • Mild vaginitis
  • Mucopurulent [mucus + pus] vaginal discharge
  • Yellow-green discharge [cervix infection]
  • Painful urination

Question 4

Eye infections in Newborns

Answer 4

• Acquired as child passes through birth canal
• Antimicrobial ointment

Question 5

In males, gonorrhea can lead to inflammmation of …

Answer 5

urethra, prostate gland, testes, and rectum

(urethritis, prostatitis, orchitis, proctitis)

Question 6

Damage to heart valves and joint tissue due to ___ ____ ____.

Answer 6

immune complex deposition (auto-immune response)

Question 7

Virulence Factors of Chlamydia (7)

Answer 7

• Fimbriae adhesions [genitourinary sys.]
• Siderophore: Fe³⁺ acquisition sys.
• Phagocyte survival
• LPS toxin
• [2] proteases that degrade Ab heavy chain
• Antigenic variation
• Antibiotic resistance

FAPA PLS

Question 8

Antibiotic Susceptibility of Gonorrhea

Answer 8

• N. gonorrheae has evolved= extensively resistant
  
  • Cephalosporins are last available
  • single 500mg intramuscular ceftriaxone (uncomplicated infection)
    
    • ß-lactam
• Coinfection w/ chlamydia
  
  • 100 mg oral doxycycline (twice / 7 days)

Question 9

Clark County has a ____ incidence of gonorrhea.

Answer 9

HIGHHHH

Question 10

Reported gonorrhea was high in females aged ____ and ____.

Answer 10

20-24 (737.4) and 15-19 (559.5)

(per 100k females)

Question 11

Reported gonorrhea was high in males aged ____ and ____.

Answer 11

20-24 (743.5) and 25-29 (700.6)

(per 100k males)

Question 12

Rate of gonorrhea among Black females was ___ times the rate among White females

Rate of gonorrhea among Black males was ___ times the rate among White males.

Answer 12

6.8

8.8

Question 13

Rate of gonorrhea among AI/AN females was ___ times the rate among White females.

Rate of gonorrhea among AI/AN males was ___ times the rate among White males.

Answer 13

6.6

3.4

Question 14

Among those tested for gonorrhea, __% are men who have sex with men, ___% are men who have sex with women only, and __% are women.

Answer 14

20.6

9.5

4.2