les 7 Flashcards

1
Q

Ontwikkeling en rijping T en B-cellen

A

Ontwikkeling in beenmerg

B-cel Verdere rijping in beenmerg
T-cel rijping in thymus

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2
Q

Waar vind positieve selectie plaats T-cel

A

cortex,

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3
Q

Wat is positieve selectie T-cellen

A

binding MHC I / II corticale epithelia sterke

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4
Q

Waar vindt negatieve selectie plaats

A

MEdulla, lokale macrofagen

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5
Q

Wat is negatieve selectie T-cellen

A

macrofagen presentatie lichaamseigen peptiden. Bij affiniteit gaan t-cellen in apoptose

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6
Q

Functie Tc-cel

A

doden virus geïnfecteerde cellen (CD8)

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7
Q

Functie Th-cel

A

produceren activeren cytokinen voor b-cellen (CD4)

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8
Q

Circulatie T-cellen

A

BLoedvat -> HEV -> lymfeknoop -> T-cel gebied cortex -> verlaten lymfeknoop via vene of lymfe

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9
Q

Homing

A

Het opnemen van t-cellen in verschillende weefsels door specifieke adhesie receptoren (CAM)

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10
Q

Onrijpe dendritsche

A

weinig MHC II moleculen veel AG receptoren

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11
Q

Rijpe dendritische

A

veel MHC II

Weinig receptoren ag

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