Lepirudin Flashcards
1
Q
Therapeutic Classification
A
Anticoagulant
2
Q
Pharmacologic Classification
A
Direct thrombin inhibitor
3
Q
Mechanism of Action
A
Directly inhibits action of thrombin without requiring intermediate step of antithrombin III inhibition. No specific antidote for lepirudin overdose.
4
Q
Indications
A
HIT (heparin induced thrombocytopenia)
5
Q
Contraindications
A
- Active bleeding
- aPTT ratio >2.5
6
Q
Adverse Effects
A
- *Abnormal bleeding
- Bleeding from puncture/wound site
- Epistaxis (nosebleed)
- Hematuria
- Vaginal bleeding
- GI bleeding
- Hypersensitivity (including anaphylaxis)
7
Q
Drug interactions with oral anticoagulants?
A
Increased effect
8
Q
Drug interactions with drugs that inhibit platelet aggregation? (e.g. aspirin, indomethacin, and ibuprofen)
A
Bleeding
9
Q
Drug interactions with ginger, garlic, green tea, feverfew, and gingko?
A
Increased risk of bleeding
10
Q
pregnancy category?
A
Pregnancy Category B
11
Q
Nursing Considerations
A
- Complete health history
- Baseline blood tests
- Monitor aPTT
- Collect blood for testing 30 minutes prior to dose
- Monitor for signs of bleeding
- Do not give oral anticoagulants
12
Q
Patient & Family Teaching
A
- Immediately report unusual bleeding
- Avoid activities that may result in injury
- Do not take other drugs or supplements
- Immediately report suspected pregnancy
- Do not breastfeed
